In silico analyses of metagenomes from human atherosclerotic plaque samples

Microbiome
Suparna MitraMichael Givskov

Abstract

Through several observational and mechanistic studies, microbial infection is known to promote cardiovascular disease. Direct infection of the vessel wall, along with the cardiovascular risk factors, is hypothesized to play a key role in the atherogenesis by promoting an inflammatory response leading to endothelial dysfunction and generating a proatherogenic and prothrombotic environment ultimately leading to clinical manifestations of cardiovascular disease, e.g., acute myocardial infarction or stroke. There are many reports of microbial DNA isolation and even a few studies of viable microbes isolated from human atherosclerotic vessels. However, high-resolution investigation of microbial infectious agents from human vessels that may contribute to atherosclerosis is very limited. In spite of the progress in recent sequencing technologies, analyzing host-associated metagenomes remain a challenge. To investigate microbiome diversity within human atherosclerotic tissue samples, we employed high-throughput metagenomic analysis on: (1) atherosclerotic plaques obtained from a group of patients who underwent endarterectomy due to recent transient cerebral ischemia or stroke. (2) Presumed stabile atherosclerotic plaques obtained from a...Continue Reading

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Citations

Sep 28, 2016·Frontiers in Cardiovascular Medicine·James S Lawson
Dec 3, 2016·Nature Reviews. Cardiology·Annika Lindskog Jonsson, Fredrik Bäckhed
Mar 23, 2017·Journal of Oral Microbiology·J-L C MougeotF K B Mougeot
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Mar 15, 2020·Microbiome·Negin KazemianSepideh Pakpour
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Sep 19, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Zhan-Zhi ZhaoZhi-Sheng Jiang
Apr 6, 2021·Frontiers in Cellular and Infection Microbiology·Yinwei ChenLi Wang
Apr 13, 2021·Frontiers in Nutrition·Rodrigo A MatosJoan Sabaté
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Aug 21, 2021·Frontiers in Cardiovascular Medicine·Xinyi ShenZhongqun Wang
Aug 27, 2021·Metabolites·Kiera MurphyCatherine Stanton
Oct 12, 2021·Frontiers in Neurology·Vishakha SharmaVida Abedi

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Datasets Mentioned

BETA
SRP040611

Methods Mentioned

BETA
PCR
whole-genome shotgun
Chip
Fluorescence

Software Mentioned

BLASTX
bowtie
blast
RapSearch
MEGAN
MEGAN5

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