In silico analysis of glycosylation pattern in 5th-6th repeat sequence of reelin glycoprotein.

Journal of Biomolecular Structure & Dynamics
Ramiz Demir, Remziye Deveci

Abstract

Reelin is an extracellular matrix glycoprotein that plays a key role in cortical development, maturation, synaptic plasticity, and memory formation in the adult mammalian brain. Glycosylation is a significant post- and co-translational modification of proteins. Although glycosylation contributes to the characteristic of proteins from their production to molecular interactions, the knowledge about the glycosylation pattern of reelin is very limited. In this study, we aimed to predict the potential glycosylation pattern of the 5th-6th repeat of central reelin fragment that responsible for their signaling, by using in silico methods. We found that the predicted glycosylation pattern of the 5th-6th repeat of human reelin was highly conserved between vertebrate species. However, this conservation was not observed in analyzed invertebrates. For the first time, we described the sites of glycosylation at a three-dimensional protein structure in human reelin. Because the sites were very closed to EGF-like repeats and receptor binding sites, they could contribute the interaction with a partner of reelin in addition to the effect of thermostability to protein. Many of the residues related glycosylation were also conserved in analyzed spec...Continue Reading

References

Jun 1, 1994·Glycoconjugate Journal·M Verma, E A Davidson
Feb 1, 1996·Glycoconjugate Journal·E F HounsellD V Renouf
Jul 23, 1998·Critical Reviews in Biochemistry and Molecular Biology·P Van den SteenG Opdenakker
Dec 10, 1998·Nucleic Acids Research·R GuptaJ E Hansen
Nov 26, 1999·Neuron·G D'ArcangeloT Curran
Aug 25, 2001·Annual Review of Neuroscience·D S Rice, T Curran
Dec 26, 2001·Brain Research. Molecular Brain Research·H IchiharaH Toh
Jan 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yves JossinAndré M Goffinet
Jun 17, 2005·Journal of Pharmaceutical Sciences·Angus M Sinclair, Steve Elliott
Jul 16, 2005·Proteins·Robert J AndersonXuliang Jiang
Sep 16, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gloria KuoJonathan A Cooper
Dec 15, 2005·Zoology : Analysis of Complex Systems, ZACS·Roland Schauer
Mar 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Arancha Botella-LópezJavier Sáez-Valero
Apr 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yves JossinAndré M Goffinet
Jun 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Norihisa YasuiJunichi Takagi
Sep 12, 2007·Bioinformatics·M A LarkinD G Higgins
Jan 25, 2008·BMC Bioinformatics·Yang Zhang
Dec 17, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tae-Ju Park, Tom Curran
Nov 20, 2009·Journal of Biochemistry·Jun HosekiKazuhiro Nagata
Dec 23, 2009·Neurobiology of Disease·Arancha Botella-LópezJavier Sáez-Valero
Mar 13, 2010·Structure·Norihisa YasuiJunichi Takagi
Nov 9, 2010·Proteins·Srinivas RamachandranNikolay V Dokholyan
Aug 17, 2011·The Journal of Biological Chemistry·Norihisa YasuiJunichi Takagi
Jun 23, 2012·Nature Reviews. Molecular Cell Biology·Kelley W MoremenAlison V Nairn
Apr 16, 2013·The EMBO Journal·Catharina SteentoftHenrik Clausen
Aug 21, 2013·PloS One·Inmaculada Cuchillo-IbáñezJavier Sáez-Valero
Apr 23, 2014·Nucleic Acids Research·Xavier Robert, Patrice Gouet
Jun 28, 2014·Neuroscience Research·Katsutoshi SekineKazunori Nakajima
Dec 31, 2014·Nature Methods·Jianyi YangYang Zhang
Jul 16, 2015·Glycobiology·Amanda R Haltom, Hamed Jafar-Nejad
Dec 31, 2015·Bioinformatics and Biology Insights·Malini ManoharanRamanathan Sowdhamini
Feb 28, 2016·Molecular Biology and Evolution·Jaime Huerta-CepasPeer Bork
Aug 9, 2016·Brain Research Bulletin·Willayat Y WaniJianhua Zhang
Oct 16, 2016·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Elvira Khialeeva, Ellen M Carpenter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Arancha Botella-LópezJavier Sáez-Valero
Nature Reviews. Neuroscience
Fadel Tissir, A M Goffinet
Journal of Alzheimer's Disease : JAD
Inmaculada Cuchillo-IbañezJavier Sáez-Valero
© 2021 Meta ULC. All rights reserved