In silico analysis of the molecular mechanism of postmenopausal osteoporosis

Molecular Medicine Reports
Yanqing LiuLili Xu

Abstract

Postmenopausal osteoporosis (PO) is a common disease in females >50 years of age worldwide and is becoming an increasing burden to society. The present study aimed to assess the molecular mechanism of PO using bioinformatic methods. The gene expression data from patients with PO and normal controls were downloaded from the ArrayExpress database provided by European Bioinformatics Institute. Following the screening of the differentially expressed genes (DEGs) using the Limma package in R language, Kyoto Encyclopedia of Genes and Genomes pathways enrichment analysis was performed using the Database for Annotation, Visualization and Integrated Discovery online tools. Sequentially, modulators of the DEGs, including transcription factors (TFs) and microRNAs, were predicted by the ChIP Enrichment Analysis databases and WEB‑based GEne SeT AnaLysis Toolkit system, respectively. In addition, the protein‑protein interaction network of DEGs was constructed via the search tool for the retrieval of interacting genes and then the functional modules were further analyzed via the clusterMaker package and The Biological Networks Gene Ontology package within the Cytoscape software. A total of 482 DEGs, including 279 upregulated and 203 downregul...Continue Reading

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Citations

May 9, 2019·International Journal of Molecular Sciences·Li-Ru ChenKuo-Hu Chen
May 20, 2020·The Journal of Obstetrics and Gynaecology Research·Randong WangYingnan Li
Dec 21, 2018·Molecular Medicine Reports·Chenggang YangXiaofeng Shi
Mar 25, 2019·Experimental and Therapeutic Medicine·Ya-Peng ZhangHui Leng
Jan 27, 2019·JBMR Plus·Vincent Ka-Fai ChengChing-Lung Cheung
Dec 29, 2020·Frontiers in Aging Neuroscience·Robert A Culibrk, Mariah S Hahn
Nov 21, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ellen E QuillenTodd L Bredbenner

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Datasets Mentioned

BETA
E-MEXP-1618

Methods Mentioned

BETA
biopsies
biopsy
ChIP

Software Mentioned

ChEA
WebGestalt
BiNGO
Cytoscape
Database for Annotation , Visualization and Integrated Discove...
GEne SeT AnaLysis Toolkit ( WebGestalt )
STRING
Biological Networks Gene Ontology ( BiNGO )
Limma
clusterMaker

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