Abstract
The overall process of protein biosynthesis across all domains of life is similar; however, detailed insights reveal a range of differences in the proteins involved. For decades, the process of protein translation in archaea has been considered to be closer to eukaryotes than to bacteria. In archaea, however, several homologues of eukaryotic proteins involved in translation initiation have not yet been identified; one of them being the initiation factor eIF2B consisting of five subunits (α, β, γ, δ and ε). Three open reading frames (PH0440, PH0702 and PH0208) in Pyrococcus horikoshii have been proposed to encode for the α-, β- and δ-subunits of aIF2B, respectively. The crystal structure of PH0440 shows similarity toward the α-subunit of eIF2B. However, the capability of PH0702 and PH0208 to function as the β- and δ-subunits of eIF2B, respectively, remains uncertain. In this study, we have taken up the task of annotating PH0702 and PH0208 using bioinformatics methods. The phylogenetic analysis of protein sequences belonging to IF2B-like family along with PH0702 and PH0208 revealed that PH0702 belonged to methylthioribose-1-phosphate isomerase (MTNA) group of proteins, whereas, PH0208 was found to be clustered in the group of rib...Continue Reading
References
Jan 1, 1994·Biochimie·N Price, C Proud
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A M CiganA G Hinnebusch
Mar 15, 1996·European Journal of Biochemistry·V M Pain
Nov 1, 1996·Molecular and Cellular Biology·W Yang, A G Hinnebusch
Mar 1, 1997·Molecular and Cellular Biology·G D PavittA G Hinnebusch
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·N C Kyrpides, C R Woese
Mar 21, 1998·Genes & Development·G D PavittA G Hinnebusch
Dec 11, 1999·Nucleic Acids Research·H M BermanP E Bourne
Jun 27, 2000·Bioinformatics·L J McGuffinD T Jones
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·N A BakerJ A McCammon
Jun 26, 2003·Nucleic Acids Research·Patrice GouetEmmanuel Courcelle
Jun 26, 2003·Nucleic Acids Research·T Andrew BinkowskiJie Liang
Oct 11, 2003·Science·Hiroki AshidaAkiho Yokota
Jun 9, 2004·Biochemical and Biophysical Research Communications·Yoshimitsu KakutaMakoto Kimura
Jun 25, 2004·The Journal of Biological Chemistry·Mario BumannUlrich Baumann
Dec 2, 2004·Acta Crystallographica. Section D, Biological Crystallography·E Krissinel, K Henrick
Jun 28, 2005·Nucleic Acids Research·Johannes SödingAndrei N Lupas
Jun 1, 2006·Proteins·Arun S KonagurthuArthur M Lesk
Feb 17, 2007·Science·Takaaki SatoTadayuki Imanaka
Oct 30, 2007·Protein Science : a Publication of the Protein Society·Fred P DavisAndrej Sali
Nov 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Laure YatimeEmmanuelle Schmitt
Feb 28, 2009·Nature Protocols·Lawrence A Kelley, Michael J E Sternberg
Jul 21, 2009·Journal of Molecular Biology·Kamal DevAlan G Hinnebusch
Jul 28, 2009·Journal of Molecular Biology·Takuya B HiyamaShigeyuki Yokoyama
Jan 23, 2010·Nature Reviews. Molecular Cell Biology·Richard J JacksonTatyana V Pestova
Apr 13, 2010·Acta Crystallographica. Section D, Biological Crystallography·P EmsleyK Cowtan
Jan 27, 2011·Biochemical Society Transactions·Dario Benelli, Paola Londei
Jan 13, 2012·The Journal of Biological Chemistry·Peter J ReidGraham D Pavitt
Jul 21, 2012·Cold Spring Harbor Perspectives in Biology·Alan G Hinnebusch, Jon R Lorsch
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Nov 30, 2013·Nucleic Acids Research·Robert D FinnMarco Punta
May 2, 2014·Nucleic Acids Research·Marco BiasiniTorsten Schwede
May 9, 2014·Biochemistry·Andrew M BogoradAssen Marintchev
Oct 29, 2014·Nucleic Acids Research·UNKNOWN UniProt Consortium
Citations
Dec 21, 2018·Microbiology and Molecular Biology Reviews : MMBR·Bjarne Hove-JensenM Cemre Manav
Feb 1, 2018·Scientific Reports·Prerana Gogoi, Shankar Prasad Kanaujia
Feb 24, 2019·International Journal of Molecular Sciences·Emmanuelle SchmittYves Mechulam
Jun 27, 2019·Journal of Receptor and Signal Transduction Research·Prajisha JayaprakashJeyaraman Jeyakanthan
Oct 20, 2020·Frontiers in Microbiology·Emmanuelle SchmittYves Mechulam