In silico assessment of gene function involved in cysteine biosynthesis in Arabidopsis: expression analysis of multiple isoforms of serine acetyltransferase

Amino Acids
M NojiK Saito

Abstract

In plants, the inorganic sulfur is first fixed into cysteine by the cysteine biosynthetic pathway. This biosynthetic pathway of cysteine involves several enzymatic reactions. In Arabidopsis thaliana, multiple isoforms seem to participate in each enzymatic step for cysteine biosynthesis. To obtain more insights on the specific role of each isoform involved in the cysteine biosynthesis, in silico analysis of these isoforms using Arabidopsis expressed sequence tags (EST) database was carried out. This EST database analysis revealed distinct population distribution of ESTs among multiple isoforms, suggesting that each isoform has its particular expression pattern, presumably associated with its specific role in cysteine biosynthesis. As another in silico analysis, co-expression analysis of genes involved in sulfur metabolism in Arabidopsis was performed using a public transcriptome database of DNA microarrays. This co-expression analysis also suggested specific function and co-regulation of some isoform genes for cysteine biosynthesis by consideration on the clustering of co-expressed genes. From the results of sensitivity to feedback regulation, subcellular localization and expression of mRNA analyses, each serine acetyltransferas...Continue Reading

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Citations

Nov 21, 2007·Plant Physiology·Mutsumi WatanabeKazuki Saito
Apr 15, 2010·BMC Plant Biology·Anja BuhtzJulia Kehr
Feb 17, 2007·Chembiochem : a European Journal of Chemical Biology·Johannes NotniErnst Anders
Mar 16, 2011·The Plant Journal : for Cell and Molecular Biology·Cintia G KawashimaStanislav Kopriva
Aug 8, 2007·Journal of Anesthesia·Michiaki Yamakage, Akiyoshi Namiki
May 23, 2017·Journal of Biomolecular Structure & Dynamics·Mahmoud Abd El-Monem El-HasabTarek Faathy El-Moselhy

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