In silico design of a triple-negative breast cancer vaccine by targeting cancer testis antigens

BioImpacts : BI
Sepideh ParvizpourYadollah Omidi

Abstract

Introduction: Triple-negative breast cancer (TNBC) is an important subtype of breast cancer, which occurs in the absence of estrogen, progesterone and HER-2 receptors. According to the recent studies, TNBC may be a cancer testis antigen (CTA)-positive tumor, indicating that the CTA-based cancer vaccine can be a treatment option for the patients bearing such tumors. Of these antigens (Ags), the MAGE-A family and NY-ESO-1 as the most immunogenic CTAs are the potentially relevant targets for the development of an immunotherapeutic way of the breast cancer treatment. Methods: In the present study, immunoinformatics approach was used to design a multi-epitope peptide vaccine to combat the TNBC. The vaccine peptide was constructed by the fusion of three crucial components, including the CD8+ cytotoxic T lymphocytes (CTLs) epitopes, helper epitopes and adjuvant. The epitopes were predicted from the MAGE-A and NY-ESO-1 Ags. In addition, the granulocyte-macrophage-colony-stimulating factor (GM-CSF) was used as an adjuvant to promote the CD4+ T cells towards the T-helper for more strong induction of CTL responses. The components were conjugated by proper linkers. Results: The vaccine peptide was examined for different physiochemical...Continue Reading

References

Oct 1, 1976·Science·P C Nowell
Sep 1, 1993·Protein Science : a Publication of the Protein Society·C Colovos, T O Yeates
Jun 27, 2000·Bioinformatics·L J McGuffinD T Jones
Nov 2, 2001·Nature·T ReyaI L Weissman
Mar 14, 2002·Journal of Neuroscience Research·Philip A Barker, Amir Salehi
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brian LivingstonAlessandro Sette
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stéphanie Graff-DuboisKostas Kosmatopoulos
Sep 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey D AhlersJay A Berzofsky
Jul 21, 2004·Journal of Computational Chemistry·Eric F PettersenThomas E Ferrin
Dec 21, 2004·Nucleic Acids Research·Amos BairochLai-Su L Yeh
Jun 28, 2005·Nucleic Acids Research·Andreas GroteDieter Jahn
Jul 22, 2005·Nature Reviews. Cancer·Andrew J G SimpsonLloyd J Old
Jul 18, 2006·Nucleic Acids Research·Sudipto Saha, G P S Raghava
Sep 19, 2006·Advanced Drug Delivery Reviews·Sjoerd H van der BurgCornelis J M Melief
May 23, 2007·Nucleic Acids Research·Markus Wiederstein, Manfred J Sippl
Jul 6, 2007·Leukemia·J H Kessler, C J M Melief
Apr 18, 2008·Nature Reviews. Cancer·Cornelis J M Melief, Sjoerd H van der Burg
Apr 23, 2008·Current Protocols in Bioinformatics·Narayanan EswarAndrej Sali
May 23, 2008·Journal of Molecular Recognition : JMR·Yasser El-ManzalawyVasant Honavar
Oct 8, 2008·Nucleic Acids Research·Luiz Gonzaga AlmeidaAna Tereza R Vasconcelos
Sep 2, 2009·Cancer Science·Otavia L Caballero, Yao-Tseng Chen
Nov 13, 2009·Nucleic Acids Research·Randi VitaBjoern Peters
Jul 9, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G CuriglianoA Goldhirsch
Nov 5, 2010·Journal of Immunological Methods·Yohan KimBjoern Peters
Dec 3, 2010·Cancer Biology & Therapy·Zheng-Cai JiaYu-Zhang Wu
Aug 5, 2011·Bioinformation·Jafar RazmaraSepideh Parvizpour
Nov 26, 2011·Medical Oncology·Tanja Badovinac ČrnjevićNera Šarić
Dec 24, 2011·Nature·Ira MellmanGlenn Dranoff
Jan 10, 2013·PLoS Computational Biology·Jens Vindahl KringelumMorten Nielsen
Jun 6, 2013·Nucleic Acids Research·Lim HeoChaok Seok
Aug 21, 2013·Human Vaccines & Immunotherapeutics·Lingxiao ZhaoHua Cong
Feb 12, 2014·Journal of Theoretical Biology·Navid NezafatEskandar Omidinia
Oct 14, 2014·Expert Opinion on Therapeutic Targets·Anselmo PapaFederica Tomao
Sep 8, 2015·Current Opinion in Cell Biology·Jenny L Weon, Patrick Ryan Potts
May 22, 2016·Journal of Biomolecular Structure & Dynamics·Sepideh ParvizpourAbdul Munir Abdul Murad
Jan 1, 2013·ImmunoTargets and Therapy·Deepa Kolaseri KrishnadasKenneth G Lucas
Dec 19, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Nasim HajighahramaniYounes Ghasemi
Mar 18, 2017·Immunotherapy·Wan-Lun YanShih-Jen Liu
Nov 18, 2017·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Hongyan JiaJin-Ming Yang

❮ Previous
Next ❯

Citations

Feb 25, 2020·Scandinavian Journal of Immunology·Minjun MaLan Wang
Jul 11, 2020·Expert Review of Vaccines·Kimia KardaniAli Namvar
Dec 9, 2020·Molecular & Cellular Proteomics : MCP·Annika NeldeJuliane Sarah Walz
Feb 16, 2021·Molecular & Cellular Proteomics : MCP·Annika NeldeJuliane S Walz
Mar 24, 2021·Cell Proliferation·Wensi LiuJianping Li
Apr 29, 2021·Seminars in Cancer Biology·Chunmei FanYong Li
Sep 25, 2021·Critical Reviews in Microbiology·Roghayeh MohammadzadehHadi Farsiani
Nov 4, 2021·Journal of Cellular Biochemistry·Debashrito DebAnurag P Srivastava

❮ Previous
Next ❯

Datasets Mentioned

BETA
GM-CSF

Software Mentioned

UCSF Chimera
GROMACS
PSIPRED
PSI
JCat
discoTope
LigPlot
Hex
BCPred
CHECK

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Breast Cancer Triple-N

Breast cancer cells have receptors for estrogen, progesterone, HER2 receptors (also called ERBB2). Triple-negative breast cancers do not have any of these receptors. Here are the latest discoveries pertaining to triple-negative breast cancers.