In Silico Identification of SOX1 Post-Translational Modifications Highlights a Shared Protein Motif.

Cells
Azaz AhmadVirginie Sottile

Abstract

The transcription factor SOX1 is a key regulator of neural stem cell development, acting to keep neural stem cells (NSCs) in an undifferentiated state. Postnatal expression of Sox1 is typically confined to the central nervous system (CNS), however, its expression in non-neural tissues has recently been implicated in tumorigenesis. The mechanism through which SOX1 may exert its function is not fully understood, and studies have mainly focused on changes in SOX1 expression at a transcriptional level, while its post-translational regulation remains undetermined. To investigate this, data were extracted from different publicly available databases and analysed to search for putative SOX1 post-translational modifications (PTMs). Results were compared to PTMs associated with SOX2 in order to identify potentially key PTM motifs common to these SOXB1 proteins, and mapped on SOX1 domain structural models. This approach identified several putative acetylation, phosphorylation, glycosylation and sumoylation sites within known functional domains of SOX1. In particular, a novel SOXB1 motif (xKSExSxxP) was identified within the SOX1 protein, which was also found in other unrelated proteins, most of which were transcription factors. These resu...Continue Reading

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Methods Mentioned

BETA
sumoylation
acetylation
glycosylation

Software Mentioned

IBS Illustrator for
Clustal
VIENNA
PhosphositePlus
Rampage
ProSA Web
Uniprot
TASSER
NetPhosK
Modeller

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