In silico modeling of interstitial lung mechanics: implications for disease development and repair.

Drug Discovery Today. Disease Models
Bélâ SukiJason H T Bates

Abstract

In this perspective, we first review some of the published literature on structural modeling of the mechanical properties of the lung parenchyma. Based on a recent study, we demonstrate why mechanical dysfunction accompanying parenchymal diseases such as pulmonary fibrosis and emphysema can follow a very different course from the progression of the underlying microscopic pathophysiology itself, particularly in the early stages. The key idea is related to the concept of percolation on elastic networks where the bulk modulus of the network suddenly changes when the fibrotic stiff regions or the emphysematous holes become suddenly connected across the network. We also introduce the concept of depercolation as a basis for the rational optimization of tissue repair. Specifically, we use these network models to predict the functional improvements that a hypothetical biological or tissue engineering repair could achieve. We find that rational targeted repair can have significant benefits over generic random repair. This concept may find application in the treatment of lung fibrosis, surgical, bronchoscopic, or biological lung volume reduction, or any future alveolar regeneration or tissue engineering solution to the repair of connecti...Continue Reading

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Citations

Sep 22, 2012·American Journal of Respiratory and Critical Care Medicine·Jason Rock, Melanie Königshoff
Dec 21, 2010·American Journal of Respiratory Cell and Molecular Biology·Hiroshi HamakawaBéla Suki
Jun 7, 2014·Drug Discovery Today. Disease Models·Béla Suki, Harikrishnan Parameswaran
May 20, 2008·Respiratory Physiology & Neurobiology·Béla Suki, Jason H T Bates
Feb 26, 2013·Biochimica Et Biophysica Acta·Rebecca G Wells
Apr 29, 2015·Computers in Biology and Medicine·Kenichiro Koshiyama, Shigeo Wada
Jun 28, 2016·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Graham M Donovan
Mar 29, 2016·International Journal for Numerical Methods in Biomedical Engineering·Christian J RothWolfgang A Wall
Apr 24, 2013·Hippocampus·Sasa L KivisaariKirsten I Taylor
Mar 18, 2020·Advanced Healthcare Materials·Matthew D DavidsonRebecca G Wells
Sep 28, 2017·Acta Odontologica Scandinavica·Carlo BertoldiDavide Zaffe
Oct 7, 2010·The Journal of Biological Chemistry·Ran YouPaula J McKeown-Longo
Dec 9, 2014·New Journal of Physics·Cláudio L N OliveiraBéla Suki
Oct 27, 2018·Tissue Engineering. Part C, Methods·Daniel E GormanHarald C Ott
Feb 5, 2011·Journal of Applied Physiology·David W KaczkaZoltán Hantos

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