In silico vaccine design against Chlamydia trachomatis infection

Network Modeling and Analysis in Health Informatics and Bioinformatics
Shilpa ShiragannavarVandana Barot

Abstract

Chlamydia trachomatis, a gram-negative bacterium known to infect the genital sites mainly columnar epithelial cells of the cervix, urethra and rectum in women and causes acute epididymitis, urinary tract inflammation and DNA damage to the sperms in men, hence considered to be one of the major sexually transmitted infections. The infection is asymptomatic in many people and remains untreated leading to serious health complications, including pelvic inflammatory disease, ectopic pregnancy and infertility. The current treatment options include antibiotics, but the pathogen has gained resistance against many antibiotics. The present work involves an in silico reverse vaccinology approach for identifying the immunogens as vaccine candidates that can be effective against reinfections and should be capable of inducing long-term protective immunity against Chlamydial infections. This study identifies the putative vaccine candidates that are membrane bound with high antigenicity properties; antigenicity induces the immunogenicity which involves identification of T-cell and B-cell epitopes that induce both humoral and cell-mediated immunity. The epitopes 'LSWEMELAY', 'LSNTEGYRY', 'TSDLGQMEY', 'FIDLLQAIY' and 'FSNNFSDIY' were predicted as...Continue Reading

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Citations

Mar 9, 2021·Expert Review of Vaccines·Luis M de la MazaSukumar Pal

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Methods Mentioned

BETA
chemical treatment
X-ray

Software Mentioned

IEDB
PSORTb
FSNNFSDIY
BepiPred
Chimera
LSWEMELAY
TSDLGQMEY
Allertop
DINC
AutoDock Vina

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