In situ adenoviral interleukin 12 gene transfer confers potent and long-lasting cytotoxic immunity in glioma

Cancer Gene Therapy
Yunhui LiuJohn S Yu

Abstract

Interleukin 12 (IL-12) isa cytokine that promotesan antitumor Th1-type pattern of differentiation in mature naïveT cells. Despite its therapeutic success in multiple animal models of cancer, the utility of systemically administered recombinant cytokine has been limited by its toxicity. This has encouraged the development of local IL-12 delivery systems through gene transfer. To determine the effect of local adenoviral delivery of IL- 12 on glioma immunogenicity, mice bearing GL-26 gliomas in the right corpus striatum were treated with direct intratumoral administration of AdmIL-12, AdLacZ, or normal saline. Survival was significantly prolonged in AdmIL-12-treated animals and immunohistochemistry demonstrated robust CD4+ and CD8+ T-cell infiltration in these mice compared to the two control groups. Glioma-infiltrating T lymphocytes from mice that received AdmIL-12 also demonstrated relatively increased, albeit statistically nonsignificant tumor killing. Based on IL-12's known ability to enhance Th1-type cytotoxic antitumor immune responses, we postulate our findings to be a result of localized induction of tumor immunity.

References

Dec 15, 1991·Journal of Immunological Methods·P Matzinger
Jan 1, 1994·Annual Review of Immunology·R A Seder, W E Paul
Jan 1, 1994·Annual Review of Immunology·S Romagnani
Oct 1, 1993·The Journal of Experimental Medicine·M J BrundaM K Gately
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·M CarusoS H Chen
Oct 31, 1996·Annals of the New York Academy of Sciences·H FujiwaraT Hamaoka
Nov 1, 1996·Journal of Immunotherapy with Emphasis on Tumor Immunology : Official Journal of the Society for Biological Therapy·R C ThompsonH Brem
May 9, 1998·Neurosurgery·W C JeanW C Low
Aug 26, 1998·British Journal of Cancer·H KishimaT Hakakawa
Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·J N ParkerJ M Markert
Mar 4, 2000·Journal of Neurosurgery·F DiMecoA Olivi

❮ Previous
Next ❯

Citations

Oct 6, 2009·Breast Cancer Research and Treatment·Michael S SabelAlfred E Chang
Feb 14, 2006·Cell Research·Cheng QianJesus Prieto
Nov 28, 2013·The Journal of Experimental Medicine·Johannes Vom BergBurkhard Becher
Jun 29, 2010·Cancer Biotherapy & Radiopharmaceuticals·Xiaoling YinHoujie Liang
Mar 31, 2005·The American Journal of Dermatopathology·Jiachun X Kung, A Bernard Ackerman
Sep 25, 2012·The American Journal of Dermatopathology·Thilo GambichlerFalk G Bechara
Jul 17, 2009·The American Journal of Surgical Pathology·Pedram PouryazdanparastPedram Gerami
Dec 7, 2011·Annals of Surgery·Victoria LyoStanley P L Leong
Dec 23, 2011·Clinical & Developmental Immunology·Christopher JacksonMichael Lim
Dec 15, 2010·Future Oncology·Erik Hp van PuttenMartine Lm Lamfers
Sep 30, 2005·Neurosurgical Focus·Moneeb EhteshamReid C Thompson
Jun 4, 2010·Stem Cell Reviews and Reports·Seung U Kim
Feb 16, 2005·Developmental Neuroscience·Khalid ShahXandra O Breakefield
Jul 20, 2005·Expert Review of Neurotherapeutics·Yasuharu AkasakiJohn S Yu
Apr 21, 2006·Expert Review of Neurotherapeutics·Maciej S Lesniak
Jan 17, 2007·Expert Opinion on Biological Therapy·Jeffrey J YuJohn S Yu
Oct 6, 2004·Expert Opinion on Biological Therapy·Hideho Okada, Ian F Pollack
Apr 30, 2014·Expert Opinion on Biological Therapy·Maria G CastroPedro R Lowenstein
Dec 1, 2009·Neurosurgery Clinics of North America·Nicholas Butowski
Oct 4, 2005·Neurological Research·Christian W Sikorski, Maciej S Lesniak
Nov 1, 2003·Expert Review of Neurotherapeutics·Moneeb EhteshamJohn S Yu
Feb 17, 2010·Immune Network·Young Sang Kim
Dec 1, 2009·Neurosurgery Clinics of North America·Seunggu J HanMichael Lim
May 4, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emily K BongiornoD Craig Hooper
Jun 14, 2014·World Journal of Clinical Oncology·Nadimpalli Ravi S VarmaAli S Arbab
Jul 24, 2010·Neuropathology and Applied Neurobiology·F P RocheG J Atkins
Sep 15, 2017·American Journal of Clinical Oncology·Elizabeth ReznikA Gabriella Wernicke
Jun 7, 2006·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Farzan SiddiquiPaul R Avery
Apr 25, 2003·Cancer Control : Journal of the Moffitt Cancer Center·Liu YangKevin O Lillehei
May 12, 2009·Journal of Neuro-oncology·Isabelle M Germano, Emanuela Binello
May 22, 2004·Cancer Control : Journal of the Moffitt Cancer Center·Moneeb EhteshamJohn S Yu
Jul 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jie TangDavid W Andrews
Aug 4, 2004·Cancer Research·Karin StaflinMagnus Lindvall
Nov 13, 2020·Frontiers in Immunology·Khue G NguyenDavid A Zaharoff
Apr 2, 2021·Frontiers in Molecular Neuroscience·Kaushik BanerjeeMaria G Castro
Nov 21, 2007·Surgical Oncology Clinics of North America·Medina C KushenMaciej S Lesniak

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.