In situ analysis of a bimodal size distribution of superparamagnetic nanoparticles

Analytical Chemistry
Andreas F ThünemannSteffen Weidner

Abstract

The dispersed iron oxide nanoparticles of ferrofluids in aqueous solution are difficult to characterize due to their protective polymer coatings. We report on the bimodal size distribution of superparamagnetic iron oxide nanoparticles found in the MRI contrast agent Resovist, which is a representative example of commercial nanoparticle-based pharmaceutical formulations. The radii of the majority of the nanoparticles (>99%) range from 4 to 13 nm (less than 1% of the particles display radii up to 21 nm). The maxima of the size distributions are at 5.0 and 9.9 nm. The analysis was performed with in situ characterization of Resovist via online coupling of asymmetrical flow field-flow fractionation (A4F) with small-angle X-ray scattering (SAXS) using a standard copper X-ray tube as a radiation source. The outlet of the A4F was directly coupled to a flow capillary on the SAXS instrument. SAXS curves of nanoparticle fractions were recorded at 1-min time intervals. We recommend using the A4F-SAXS coupling as a routine method for analysis of dispersed nanoparticles with sizes in the range of 1-100 nm. It allows a fast and quantitative comparison of different batches without the need for sample preparation.

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Citations

Jan 10, 2016·Medical Physics·Laura R CroftSteven M Conolly
Aug 21, 2013·Biomedizinische Technik. Biomedical Engineering·Harald KratzJörg Schnorr
Aug 20, 2016·Physics in Medicine and Biology·P VogelV C Behr
Oct 14, 2011·Physical Chemistry Chemical Physics : PCCP·Johannes MöllerMetin Tolan
Dec 1, 2009·Analytical Methods : Advancing Methods and Applications·Andreas F ThünemannSteffen Weidner
Feb 11, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Marco LattuadaMassimo Morbidelli
Jan 19, 2011·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Eleonora V ShtykovaLyudmila M Bronstein
Apr 30, 2015·Analytical Chemistry·Jeffrey T PettyJohn F Wheeler
Jul 28, 2019·Nano Letters·Peter J SantosRobert J Macfarlane

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