In situ aquaculture methods for Dysidea avara (Demospongiae, Porifera) in the northwestern Mediterranean.

Marine Drugs
Sònia de CaraltR H Wijffels

Abstract

Marine sponges produce secondary metabolites that can be used as a natural source for the design of new drugs and cosmetics. There is, however, a supply problem with these natural substances for research and eventual commercialisation of the products. In situ sponge aquaculture is nowadays one of the most reliable methods to supply pharmaceutical companies with sufficient quantities of the target compound. In this study, we focus on the aquaculture of the sponge Dysidea avara (Schmidt, 1862), which produces avarol, a sterol with interesting pharmaceutical attributes. The soft consistency of this species makes the traditional culture method based on holding explants on ropes unsuitable. We have tested alternative culture methods for D. avara and optimized the underwater structures to hold the sponges to be used in aquaculture. Explants of this sponge were mounted on horizontal ropes, inside small cages or glued to substrates. Culture efficiency was evaluated by determination of sponge survival, growth rates, and bioactivity (as an indication of production of the target metabolite). While the cage method was the best method for explant survival, the glue method was the best one for explant growth and the rope method for bioactivity.

References

Jun 1, 1991·International Journal of Sports Medicine·W E Müller, H C Schröder
Nov 9, 2002·Journal of Biotechnology·Salvatore De RosaSimeon Popov
Jan 20, 2004·Marine Biotechnology·Detmer SipkemaRené H Wijffels
Jan 30, 2004·Biotechnology and Bioengineering·Detmer SipkemaRené H Wijffels
Jun 29, 2004·International Review of Cytology·Werner E G MüllerIsabel M Müller
Mar 2, 2005·Biotechnology and Bioengineering·Detmer SipkemaRené H Wijffels
Mar 19, 2005·Marine Biotechnology·Detmer SipkemaRené H Wijffels
Jul 13, 2007·Marine Biotechnology·Sònia de CaraltRené H Wijffels
Oct 27, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dusan Sladić, Miroslav J Gasić
May 8, 2008·Marine Biotechnology·Dominick MendolaRené H Wijffels

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Citations

Mar 14, 2012·Marine Drugs·Marina Gordaliza
Jan 15, 2014·The Science of the Total Environment·Paula Pérez-LópezMa Teresa Moreira
Nov 23, 2019·Current Drug Delivery·Arya Kadukkattil RamanunnyAnkit Awasthi
Sep 11, 2018·Critical Reviews in Biotechnology·Ilekuttige Priyan Shanura FernandoYou-Jin Jeon
Mar 1, 2021·Journal of Pharmaceutical and Biomedical Analysis·Fereshteh GolfakhrabadiMehdi Safdarian

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