In situ assembly of Ag nanoparticles (AgNPs) on porous silkworm cocoon-based wound film: enhanced antimicrobial and wound healing activity

Scientific Reports
Kun YuGuangqian Lan

Abstract

Preventing wound infection and retaining an appropriate level of moisture around wounds represent the most critical issues in wound treatment. Towards these ends, special focus has been placed on Bombyx mori cocoons because the protective function of the silkworm cocoon resembles the manner in which the skin protects the human body. We have designed a facile technique to develop a novel silkworm cocoon-based wound film (SCWF) wound dressing utilizing a CaCl2-ethanol-H2O solution. To improve the anti-bacterial performance of SCWF, we have incorporated the ability of silk sericin to act as a reducing agent for the conversion of Ag+ to Ag, yielding nanoparticles (AgNPs) linked together by peptide bonds of silkworm cocoon wound film (SCWF-AgNPs). SCWF-AgNP dressing exhibited excellent biocompatibility, anti-bacterial performance, and good extensibility. Furthermore, in vivo experiments indicated that SCWF-AgNP dressing was able to significantly accelerate the healing rate of infected wounds in New Zealand White rabbits and histological examination revealed that it aided in the successful reconstruction of intact and thickened epidermis during 14 days of healing of impaired wound tissue. These results demonstrate that the present ap...Continue Reading

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Citations

Oct 30, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Kun LiYubo Fan
Jun 21, 2019·Royal Society Open Science·Peng ZhangFeng Zhang
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Jinke YangGareth R Williams
Dec 19, 2020·Frontiers in Chemistry·Cristina Belda MarínChristophe Egles
Jun 23, 2020·Annales pharmaceutiques françaises·M ShitoleS Nangare

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