PMID: 8972758Nov 1, 1996Paper

In situ assessment of cell proliferation at the invasive front of oral squamous cell carcinomas

Virchows Archiv : an International Journal of Pathology
J PiffkòK W Schmid

Abstract

In oral squamous cell carcinoma (OSCC) the histopathological malignancy grading of the invasive front has been found to offer the most reliable prognostic parameter. In the present study we compared such tumour front grading of 100 OSCCs with the in situ growth fraction demonstrated by MIB1 immunostaining following wet autoclave antigen retrieval. MIB1 labelling indices (LIs) were estimated both at the invasive front and in the central parts of OSCCs using two different evaluation methods (overall and random counting) to investigate whether MIB1 LIs represent a possible biological background for the tumour front grading. Statistically highly significantly increased MIB1 LIs were found at the invasive tumour fronts with both counting methods compared with the centres of the same tumours. For LI estimation the classic overall counting procedure proved to be superior. However, in contrast to tumour front grading, MIB1 LIs revealed no correlation with the clinical outcome of the patients concerned. Our results demonstrate that the invasive tumour front of an OSCC is composed of (a) tumour subpopulation(s) with higher proliferative activity. However, determination of the proliferative activity by MIB1 of this tumour area offers no p...Continue Reading

Citations

Mar 16, 2013·Clinical Oral Investigations·Henning HankenMarco Blessmann
Jul 27, 2002·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Makoto NoguchiKenji Nakamori
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·S MaoK D Janda
Oct 1, 2010·Journal of Oral Science·Satiro WatanabeElismauro F Mendonça
Oct 21, 2014·Journal of Oral and Maxillofacial Pathology : JOMFP·Smita Shrishail BirajdarMohsin Gadivan
Jan 24, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Martinho Campolina Rebello HortaMaria Cássia Ferreira Aguiar
Sep 4, 2008·British Journal of Cancer·D WangsaE Munck-Wikland
Aug 21, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A PichR Navone
Feb 10, 2018·The Journal of Contemporary Dental Practice·Lipsa BhuyanSarat Nayak

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