In Situ Biological Transmutation of Catalytic Lactic Acid Waste into Calcium Lactate in a Readily Processable Three-Dimensional Fibrillar Structure for Bone Tissue Engineering.

ACS Applied Materials & Interfaces
Tae In HwangCheol Sang Kim

Abstract

A bioinspired three-dimensional (3D) fibrous structure possesses biomimicry, valuable functionality, and performance to scaffolding in tissue engineering. In particular, an electrospun fibrous mesh has been studied as a scaffold material in various tissue regeneration applications. We produced a low-density 3D polycaprolactone/lactic acid (LA) fibrous mesh (3D-PCLS) via the novel lactic-assisted 3D electrospinning technique exploiting the catalytic properties of LA as we reported previously. In the study, we demonstrated a strategy of recycling the LA component to synthesize the osteoinductive biomolecules in situ, calcium lactate (CaL), thereby forming a 3D bioactive PCL/CaL fibrous scaffold (3D-SCaL) for bone tissue engineering. The fiber morphology of 3D-PCLS and its packing degree could have been tailored by modifying the spinning solution and the collector design. 3D-SCaL demonstrated successful conversion of CaL from LA and exhibited the significantly enhanced biomineralization capacity, cell infiltration and proliferation rate, and osteoblastic differentiation in vitro with two different cell lines, MC3T3-e1 and bone marrow stem cells. In conclusion, 3D-SCaL proves to be a highly practical and accessible strategy using a...Continue Reading

References

Jan 1, 1982·Caries Research·B M ShresthaB G Bibby
Apr 30, 2005·Biomaterials·Vassilis Karageorgiou, David Kaplan
Jun 15, 2006·Tissue Engineering·Quynh P PhamAntonios G Mikos
May 18, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Deborah A Straub
Jul 22, 2008·Biomaterials·Sangamesh G KumbarCato T Laurencin
Jul 15, 2009·Biomaterials·Parthasarathy A MadurantakamGary L Bowlin
Aug 21, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·In Kyong ShimSeung Jin Lee
Feb 7, 2012·Colloids and Surfaces. B, Biointerfaces·Lanlan PanJian Wang
Feb 11, 2014·Carbohydrate Polymers·Afeesh Rajan UnnithanCheol Sang Kim
Jul 27, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Xue ZhangXu-Dong Sun
Dec 11, 2014·The New England Journal of Medicine·Jeffrey A Kraut, Nicolaos E Madias
Feb 27, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Nina LiaoCheol Sang Kim
Mar 30, 2016·Colloids and Surfaces. B, Biointerfaces·Zuyuan LuoShicheng Wei
Mar 18, 2010·Science and Technology of Advanced Materials·Wenguo CuiJiang Chang
Dec 16, 2016·Nature·Jordan J Green, Jennifer H Elisseeff
Sep 12, 2017·ACS Applied Materials & Interfaces·Sakthivel NagarajanMikhael Bechelany
Feb 3, 2013·Biomaterials Science·Paul D DaltonDietmar W Hutmacher

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