In situ biomolecule production by bacteria; a synthetic biology approach to medicine

Journal of Controlled Release : Official Journal of the Controlled Release Society
Yensi Flores BuesoMark Tangney

Abstract

The ability to modify existing microbiota at different sites presents enormous potential for local or indirect management of various diseases. Because bacteria can be maintained for lengthy periods in various regions of the body, they represent a platform with enormous potential for targeted production of biomolecules, which offer tremendous promise for therapeutic and diagnostic approaches for various diseases. While biological medicines are currently limited in the clinic to patient administration of exogenously produced biomolecules from engineered cells, in situ production of biomolecules presents enormous scope in medicine and beyond. The slow pace and high expense of traditional research approaches has particularly hampered the development of biological medicines. It may be argued that bacterial-based medicine has been "waiting" for the advent of enabling technology. We propose that this technology is Synthetic Biology, and that the wait is over. Synthetic Biology facilitates a systematic approach to programming living entities and/or their products, using an approach to Research and Development (R&D) that facilitates rapid, cheap, accessible, yet sophisticated product development. Full engagement with the Synthetic Biolo...Continue Reading

Citations

Jun 13, 2020·Expert Review of Anti-infective Therapy·Alba CortésCinzia Cantacessi
Jun 27, 2019·The ISME Journal·Glenn HoganDave J Bartley
Feb 1, 2019·Advanced Biosystems·Shrikrishnan Sankaran, Aránzazu Del Campo
Mar 11, 2020·Frontiers in Oncology·Sidney P WalkerMarcus J Claesson
Jan 8, 2021·Soft Matter·Laura K Rivera-TarazonaTaylor H Ware
Feb 25, 2021·Research : a Science Partner Journal·Fengyuan WangYuanjin Zhao
Sep 4, 2019·Analytical Chemistry·Venkata V B YallapragadaGanga C R Devarapu
Oct 14, 2021·Advanced Healthcare Materials·Erick Insuasti-CruzFrank Alexis

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