In situ biosynthesized gold nanoclusters inhibiting cancer development via the PI3K-AKT signaling pathway

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Maonan WangJiahua Zhou

Abstract

Nanomaterials have made great breakthroughs in drug delivery. However, in previous studies, nanomaterials have been mostly used as vehicles to transport drugs into tumors. Herein, we first found that the in situ biosynthesized gold nanoparticles (Au NCs) can inhibit cancer development via the inhibition of some signaling pathways. Classical cell phenotypic assay tests and orthotropic liver tumor model both showed that the in situ biosynthesized Au NCs could inhibit tumor development. With the help of the RNA-seq analysis, we found that the in situ biosynthesized Au NCs could significantly inhibit the PI3K-AKT signaling pathway, thus effectively impeding tumor development. This facile and effective tumor targeting theranostics in vivo can effectively cure cancers in future clinical applications.

References

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Citations

Mar 17, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine· TayyabaXuemei Wang
Mar 25, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zengchao GuoXuemei Wang
Feb 29, 2020·Journal of Cancer Research and Clinical Oncology·Maonan WangXuemei Wang

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Methods Mentioned

BETA
RNA-seq
PCR
electrophoresis
dynamic light scattering
X-ray
fluorescence imaging
Fluorescence

Software Mentioned

imageJ
DAVID
Image Pro Plus

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