PMID: 6983662Sep 1, 1982Paper

In-situ characterization of mononuclear cell infiltrates in lesions of multiple sclerosis

Neuropathology and Applied Neurobiology
H NylandR Matre

Abstract

The mononuclear cell infiltrates in autopsy material from brains and spinal cords of six patients with multiple sclerosis (MS) were characterized in situ. Receptors for sheep erythrocytes and anti-T lymphocyte serum were used to identify T lymphocytes. Receptors for the activated third components of complement and for the Fc-portion of IgG (Fc gamma receptors) were used as markers for macrophages and lymphocytes. In acute and recent MS lesions, perivascular infiltrates of mononuclear cells were commonly found. Most cells were T lymphocytes. Some B lymphocytes were also demonstrated. The demyelinating lesions contained large numbers of lipid macrophages expressing Fc gamma receptors. The lipid macrophages are probably derived from microglial cells. The chronic, demyelinated lesions contain a few mononuclear cells, mainly B lymphocytes and plasma cells.

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Citations

Jan 16, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·C Infante-DuarteF Zipp
Feb 1, 1989·Research in Immunology·R A Sobel
Jul 26, 2012·Annals of Neurology·John W Prineas, John D E Parratt
Dec 26, 2009·Annals of Neurology·Andrew P D HendersonJohn W Prineas
Dec 21, 2014·Proceedings of the National Academy of Sciences of the United States of America·Tae-Yoon ParkSang-Kyou Lee
Oct 31, 2007·Multiple Sclerosis : Clinical and Laboratory Research·R HöftbergerH Budka
Jan 1, 1984·Annals of the New York Academy of Sciences·U Traugott, C S Raine
Aug 14, 2013·PloS One·Marjorie S MorganMichael P Markey
Aug 21, 2003·Multiple Sclerosis : Clinical and Laboratory Research·L BøS J Mørk
Nov 12, 2015·Frontiers in Immunology·Prenitha Mercy Ignatius Arokia DossManu Rangachari
Feb 7, 2002·Journal of Neuropathology and Experimental Neurology·Jerome R WujekBruce D Trapp
Sep 24, 2021·Journal of Neuropathology and Experimental Neurology·John W Prineas, John D E Parratt

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