PMID: 6983117Oct 1, 1982Paper

In situ characterization of mononuclear cells in rheumatoid tissues, using monoclonal antibodies. No reduction of T8-positive cells or augmentation in T4-positive cells

Scandinavian Journal of Immunology
O FørreB G Solheim

Abstract

The reactivity of monoclonal mouse anti-human antibodies specific for mononuclear cell surface antigens were studied by the indirect immunofluorescence technique in frozen synovial tissue sections from patients with rheumatoid arthritis (RA). Most of the proliferating synovial lining cells were positive for HLA-DR antigens and monocyte-specific antigens, since they reacted with the OKIa1 and OKM1. Cells positive for HLA-DR and monocyte antigens were also seen scattered or in small nests in the synovial stroma, probably representing synovial cells or monocytes/macrophages. Some of the HLA-DR-positive cells may also be B lymphocytes or activated T cells. Endothelial cells were also HLA-DR antigen-positive. Monoclonal antibodies with specificity for all T cells (OKT3), for helper/inducer cells (OKT4), and for suppressor/cytotoxic cells (OKT8) reacted with cells often located in follicle-like structures around vessels. Cells with the T4 phenotype tended to be located in the centre of the follicles, whereas the T8 positive cells were more peripherally situated. In most instances fewer cells were positive for the T8 than for the T4 marker. In some instances there was as many T8-positive cells as T4-positive cells. Complete lack of T-...Continue Reading

References

Jan 1, 1978·Scandinavian Journal of Immunology·B G SolheimE Thorsby
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Citations

Jan 1, 1990·Journal of Clinical Laboratory Analysis·A B CarpenterS H Ip
Jan 1, 1989·Rheumatology International·P A Revell
Jan 1, 1988·Rheumatology International·P I Mapp, P A Revell
Jan 1, 1988·Rheumatology International·P GeborekF A Wollheim
Jan 1, 1988·Springer Seminars in Immunopathology·K WaalenJ B Natvig
Jan 1, 1988·Springer Seminars in Immunopathology·I StamenkovicJ T Kurnick
Jan 1, 1990·Rheumatology International·C R StevensP A Revell
Mar 1, 1992·Veterinary Immunology and Immunopathology·C MayD Bennett
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·I StamenkovicJ T Kurnick
Aug 1, 1985·Annals of the Rheumatic Diseases·Y T KonttinenP Slätis
Jan 1, 1987·Annals of the Rheumatic Diseases·P I Mapp, P A Revell
Feb 1, 1987·Annals of the Rheumatic Diseases·J HeinoT Kouri
Apr 19, 2000·Archives of Histology and Cytology·T IwanagaK Nozawa-Inoue
Feb 20, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H P KitamuraT Iwanaga
May 1, 1985·Scandinavian Journal of Immunology·U ForsumU Tjernlund
Jan 1, 1988·Scandinavian Journal of Rheumatology. Supplement·S GudmundssonL Klareskog
Jan 1, 1988·Scandinavian Journal of Rheumatology. Supplement·M Ziff

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