In Situ complement activation and T-cell immunity in leprosy spectrum: An immunohistological study on leprosy lesional skin

PloS One
N Bahia El IdrissiP Kumar Das

Abstract

Mycobacterium leprae (M. leprae) infection causes nerve damage and the condition worsens often during and long after treatment. Clearance of bacterial antigens including lipoarabinomannan (LAM) during and after treatment in leprosy patients is slow. We previously demonstrated that M. leprae LAM damages peripheral nerves by in situ generation of the membrane attack complex (MAC). Investigating the role of complement activation in skin lesions of leprosy patients might provide insight into the dynamics of in situ immune reactivity and the destructive pathology of M. leprae. In this study, we analyzed in skin lesions of leprosy patients, whether M. leprae antigen LAM deposition correlates with the deposition of complement activation products MAC and C3d on nerves and cells in the surrounding tissue. Skin biopsies of paucibacillary (n = 7), multibacillary leprosy patients (n = 7), and patients with erythema nodosum leprosum (ENL) (n = 6) or reversal reaction (RR) (n = 4) and controls (n = 5) were analyzed. The percentage of C3d, MAC and LAM deposition was significantly higher in the skin biopsies of multibacillary compared to paucibacillary patients (p = <0.05, p = <0.001 and p = <0.001 respectively), with a significant association...Continue Reading

References

Nov 1, 1973·The American Journal of Tropical Medicine and Hygiene·B PetchclaiT Ramasoota
Jun 1, 1974·Leprosy Review·S G Browne
May 1, 1974·The American Journal of Tropical Medicine and Hygiene·R H GelberP Fasal
Aug 8, 2002·The American Journal of Tropical Medicine and Hygiene·Diana N J LockwoodS R Khanolkar-Young
Jul 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Valeria RamagliaFrank Baas
Jan 9, 2008·Immunology and Cell Biology·Paul M KnopfAnne S De Groot
Mar 20, 2008·The American Journal of Pathology·Valeria RamagliaFrank Baas
Feb 28, 2009·Molecular Immunology·Valeria RamagliaFrank Baas
Oct 17, 2009·Molecular Immunology·Valeria RamagliaFrank Baas
Sep 3, 2010·The American Journal of Tropical Medicine and Hygiene·Ma Victoria F BalagonRoland V Cellona
Feb 4, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kees FluiterValeria Ramaglia
Mar 24, 2016·Journal of Cell Science·Rahul SureshDavid M Mosser

❮ Previous
Next ❯

Citations

Aug 10, 2018·PLoS Neglected Tropical Diseases·Gabriela Canalli KretzschmarAngelica Beate Winter Boldt
Mar 27, 2019·Journal of Tropical Medicine·Maria Aparecida Alves de Oliveira SerraMárcio Flávio Moura de Araújo
May 28, 2019·International Journal of Experimental Pathology·Fátima Regina Vilani-MorenoSílvia Cristina Barboza Pedrini
Jul 28, 2018·Pathogens and Disease·Héctor Serrano-CollNora Cardona-Castro
Apr 13, 2018·Frontiers in Immunology·Roberta Olmo PinheiroEuzenir Nunes Sarno
Mar 13, 2021·Immunological Reviews·Anouk van Hooij, Annemieke Geluk

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

GraphPad
GraphPad Prism
Image Pro Plus
Cell D

Related Concepts

Related Feeds

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.

Related Papers

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Anand IyerP Kumar Das
International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association
J Y ShenT H Rea
© 2022 Meta ULC. All rights reserved