In situ conjugation of dithiophenol maleimide polymers and oxytocin for stable and reversible polymer-peptide conjugates

Bioconjugate Chemistry
Jennifer CollinsDavid M Haddleton

Abstract

The in situ one-pot synthesis of peptide-polymer bioconjugates is reported. Conjugation occurs efficiently without the need for purification of dithiophenol maleimide functionalized polymer as a disulfide bridging agent for the therapeutic oxytocin. Conjugation of polymers was demonstrated to be reversible and to significantly improve the solution stability of oxytocin.

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Aug 1, 2015·Chemical Reviews·Athina AnastasakiDavid M Haddleton
Mar 30, 2017·Biomacromolecules·Hiteshri MakwanaCameron Alexander
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Jun 30, 2018·Bioconjugate Chemistry·Kévin RenaultCyrille Sabot
Oct 2, 2021·International Journal of Pharmaceutics·Ebtesam Abdullah Al-SuhaimiAbdelgadir M Homeida

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