In situ constructive myocardial remodeling of extracellular matrix patch enhanced with controlled growth factor release

The Journal of Thoracic and Cardiovascular Surgery
Akiko TanakaTakeyoshi Ota

Abstract

In an effort to expand treatment for advanced heart failure, we sought to develop a tissue-engineered cardiac patch for constructive and functional in situ myocardial regeneration. An extracellular matrix patch derived from porcine small intestine submucosa was incorporated with a controlled release of basic fibroblast growth factor. The patch was surgically implanted into the porcine right ventricle (group B, n = 5). Untreated extracellular matrix (group U) and Dacron (group D) patches served as control (n = 5/group). Cardiovascular magnetic resonance was performed in all 3 groups 60 days postsurgery to evaluate regional contractility with peak longitudinal strain, perfusion with relative maximum upslope, and extent of fibrosis/edema with extracellular volume fraction. Electrophysiologic-anatomic mapping was performed in group B. Histology and quantitative reverse transcription-polymerase chain reaction were performed for further tissue characterization. Cardiovascular magnetic resonance-derived parameters were significantly better in group B compared with groups U and D (strain: group B = -16.6% ± 1.8%, group U = -14.7% ± 1.2%, group D = -9.0% ± 1.5%, P < .001; upslope: group B = 13.7% ± 1.1%, group U = 10.8% ± 1.3%, group D ...Continue Reading

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Citations

Jun 22, 2018·The Keio Journal of Medicine·Naritaka Kimura
May 2, 2017·Tissue Engineering. Part a·Daniel S J ParkPaul W M Fedak
Aug 29, 2018·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·R Scott BakerDavid L S Morales
Apr 26, 2019·ESC Heart Failure·Grigorios KorosoglouSebastian Kelle
May 14, 2019·Frontiers in Cell and Developmental Biology·Simranjit S PattarPaul W M Fedak

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