Oct 28, 2016

In situ crosslinkable elastomeric hydrogel for long-term cell encapsulation for cardiac applications

Journal of Biomedical Materials Research. Part a
Remya Komeri, Jayabalan Muthu


The regenerative therapy of tissues relays on successful cell transplantation and engraftment. Soft hydrogel carriers are employed to protect transplanted cells from harmful microenvironment in soft tissue regeneration. Herein an injectable, porous, biodegradable, bioresorbable, and elastomeric hydrogel fabricated from poly(propylene fumarate-co-sebacate-co-ethylene glycol) crosslinked with PEGDA for cardiomyoblast encapsulation was reported. The hydrogel retains adequate mechanical property in the range of native myocardium even after 30 days of degradation (49 ± 0.008 kPa). The hydrogel shows maximum extensibility without collapsing even under 60% compression. The hydrogel retains 70.58% equilibrium water content, wide internal porosity, and slow bulk degradation favorable for cell carriers. The cardiomyoblast cells encapsulated in hydrogel retains viability even after 30 days of culture. The long-term viability and proliferation studies of encapsulated cells in the hydrogel substantiate the suitability of hydrogel microenvironment for cell survival. The present hydrogel is a potential cell carrier with favorable physical and biological properties for cell encapsulation for cardiac applications. The candidate hydrogels perfor...Continue Reading

  • References22
  • Citations


  • References22
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Drug Carriers
Injection Product
Ethylene Glycol Measurement
Cell Therapy
Graft Acceptance
poly(propylene fumarate)

Related Feeds

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

Related Papers

Journal of Biomedical Materials Research. Part a
Melissa J Mahoney, Kristi S Anseth
Journal of Biomedical Materials Research. Part a
Meryem O Pehlivaner Kara, Adam K Ekenseair
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Xiaowei LiXuejun Wen
© 2020 Meta ULC. All rights reserved