PMID: 9550146Apr 29, 1998Paper

In situ detection of H1-receptor mRNA and absence of apoptosis in the transient histamine system of the embryonic rat brain

The Journal of Comparative Neurology
A KinnunenP Panula

Abstract

In the developing brain, histamine is one of the first neurotransmitters to appear. The concentration of histamine in the prenatal brain is fivefold that of adult levels. During the prenatal development a large transiently histamine-immunoreactive cell population distinct from the adult histaminergic system can be found within a subpopulation of the developing serotonergic raphe nuclei neurons. Also histamine-immunoreactive nerve fibers are widely distributed already during the prenatal development extending to the diencephalon, the thalamus, the cortex, and the spinal cord. Large numbers of histamine-containing mast cells also migrate into the brain during the late prenatal life. The wide distribution and high prenatal concentrations imply important functions for the histaminergic system during intrauterine development. However, little is known about the actual functions of histamine during development, and which of the histamine receptors are present in the prenatal rat brain is currently unknown. In the present study, we used in situ hybridization to study the distribution of H1-receptor (H1R) mRNA in the embryonic rat brain and spinal cord. H1R mRNA could be detected in rat brain and in spinal cord on embryonic day (E) 14, ...Continue Reading

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Citations

Apr 19, 2008·Journal of Neurochemistry·Anayansi Molina-Hernández, Iván Velasco
Jul 11, 2012·Journal of Neurochemistry·Anayansi Molina-HernándezJosé-Antonio Arias-Montaño
Dec 9, 2014·Acta Physiologica·M Sundvik, P Panula
Feb 4, 2014·Trends in Neurosciences·Pertti PanulaKaj Karlstedt
Dec 11, 2003·Molecular and Cellular Neurosciences·Kaj KarlstedtPertti Panula
Jan 10, 2018·Frontiers in Neuroscience·Karina H SolísAnayansi Molina-Hernández
Jun 21, 2013·Nature Reviews. Neuroscience·Pertti Panula, Saara Nuutinen
Jul 16, 2008·Physiological Reviews·Helmut L HaasOliver Selbach

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis