In situ detection of retinoid-X receptor expression in normal and psoriatic human skin

The British Journal of Dermatology
J ReichrathH P Baum

Abstract

Increasing evidence suggests that the retinoid-X receptors RXR(-alpha,-beta,-gamma) play a crucial part in regulating the transcriptional activity of several steroid hormone receptors, including 1,25-dihydroxyvitamin D3 receptors (VDR) and retinoic acid receptors (RAR-alpha,-beta,-gamma). We developed a new technique for immunohistochemical in situ detection of RXR receptors, and investigated the localization of RXR-alpha in normal and psoriatic human skin using a recently raised corresponding specific antibody. RXR-alpha positive cells related to the skin were phenotyped by sequential sections and a double-labelling procedure for the simultaneous demonstration of this nuclear receptor and cell membrane antigens, as well as cytokeratin 10, HLA-DR and vimentin. Our findings indicate that: (i) RXR-alpha is strongly expressed in normal and psoriatic human skin; (ii) most of the cell types in normal human skin, including keratinocytes, melanocytes, fibroblasts and skin immune cells such as Langerhans cells, reveal strong nuclear immunoreactivity for RXR-alpha, with less cytoplasmic staining; (iii) altered levels or distribution of RXR-alpha in the skin do not appear to be involved in the genesis of psoriasis vulgaris, but subepider...Continue Reading

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Citations

Dec 18, 2003·Clinics in Dermatology·Laura WinterfieldAlan Menter
Apr 17, 2004·The Journal of Investigative Dermatology·Shinichi InoueToshiyasu Shimomura
Jun 24, 2010·Journal of Dermatological Science·Yuji Shirakata
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Oct 19, 2004·Journal of Dermatological Science·Yuji ShirakataKoji Hashimoto
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May 6, 2019·The British Journal of Dermatology·R W ClaytonX Lim
Sep 29, 2019·Pigment Cell & Melanoma Research·Jessica L FlesherAnand K Ganesan

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