PMID: 15247598Jul 13, 2004Paper

In situ diagnosis of central venous catheter-related bloodstream infection without peripheral blood culture

The Pediatric Infectious Disease Journal
Jeremy A FranklinPatricia M Flynn

Abstract

Catheter-related bloodstream infections (CRBIs) are frequent complications of the use of long term central venous catheters (CVCs). Comparative quantitative culture of blood obtained via the CVC and a peripheral vein (PV) is a well-accepted method of diagnosing CRBI; however, an alternative definition for use when a PV culture is not available is desirable. A computerized search of patient records identified all positive blood culture results from the St. Jude Children's Research Hospital Microbiology Laboratory between January 1996 and May 2001. Demographic data, catheter information and culture results were abstracted. Sensitivity, specificity, positive predictive value (PPV), and likelihood ratio were calculated for 2 alternative definitions of CRBI. Review of the medical records revealed 136 episodes of bacteremia that were evaluable for alternative definition 1 and 241 episodes that were evaluable for alternative definition 2. In patients with a double lumen CVC, CRBI can be diagnosed by a > or = 5-fold difference in colony-forming units/mL between the 2 lumens (alternative definition 1) with sensitivity, specificity, PPV and likelihood ratio of 61.8, 93.3, 92.2 and 9.22, respectively. In patients with a single or double l...Continue Reading

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Citations

Oct 18, 2005·Current Infectious Disease Reports·Rania Hanna, Issam I Raad
Apr 29, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Adrienne G RandolphDonald Goldmann
Nov 18, 2009·The Pediatric Infectious Disease Journal·Ashok SrinivasanRandall T Hayden
Oct 28, 2009·The Pediatric Infectious Disease Journal·Patricia M Flynn
Oct 17, 2006·Clinical Microbiology Reviews·Keri K Hall, Jason A Lyman
Sep 6, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Deborah TomlinsonLillian Sung
Jun 6, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Leonard A MermelDavid K Warren
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Apr 27, 2012·Pediatric Blood & Cancer·Nitza NewmanEugene Leibovitz
Sep 13, 2014·Pediatric Blood & Cancer·Mette Møller HandrupHenrik Schrøder
Jul 21, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Reineke A SchootMarianne D van de Wetering
Jun 16, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A SimonK Beutel
Apr 15, 2017·Pediatric Blood & Cancer·Ramia ZakhourIssam Raad
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Oct 14, 2006·Pediatric Blood & Cancer·Elio CastagnolaRiccardo Haupt
Jun 3, 2009·Expert Review of Anti-infective Therapy·Elio Castagnola, Maura Faraci

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