In situ electrochemical distance tunneling spectroscopy of ds-DNA molecules

Langmuir : the ACS Journal of Surfaces and Colloids
Emil WierzbinskiKrzysztof Slowinski

Abstract

The electrical conductance of ds-DNA duplexes containing 8-14 base pairs modified at both ends with a -(CH(2))(6)-SH linker was measured in a buffered aqueous solution using electrochemically controlled distance tunneling spectroscopy. The tunneling experiment with self-complementary 5'-(GC)(n)()-3'-(CH(2))(6)-SH (n = 4-7) duplexes attached covalently to a gold STM tip and a Au(111) electrode shows a wide distribution of currents independent of the ds-DNA length. The voltage-induced horizontal orientation of ds-DNA within the junction results in decreased electrical conductance. The lower currents are also observed for ds-DNA molecules containing a single CA base mismatch.

Citations

May 31, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Emil Wierzbinski, Krzysztof Slowinski
Jul 26, 2008·Nature Nanotechnology·Xuefeng GuoColin Nuckolls
Oct 4, 2008·Bioconjugate Chemistry·Marisa C Buzzeo, Jacqueline K Barton
Nov 5, 2008·Bioconjugate Chemistry·Alon A GorodetskyJacqueline K Barton
Dec 5, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Alon A GorodetskyJacqueline K Barton
Oct 13, 2006·Organic & Biomolecular Chemistry·Ulrich RantMarc Tornow
Oct 30, 2012·The Journal of Physical Chemistry. B·Emil WierzbinskiDavid H Waldeck
Jan 6, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Emil WierzbinskiDavid H Waldeck
Feb 12, 2009·Journal of the American Chemical Society·Peng XiuHaiping Fang
Apr 23, 2009·Journal of the American Chemical Society·Amit PaulDavid H Waldeck
Aug 2, 2012·Physical Chemistry Chemical Physics : PCCP·Natalie B MurenJacqueline K Barton
Oct 6, 2012·Physical Chemistry Chemical Physics : PCCP·Magdalena Gebala, Wolfgang Schuhmann
Dec 27, 2011·Bioelectrochemistry·Joanna Juhaniewicz, Slawomir Sek
Sep 6, 2007·Small·Mingsheng XuYasuhiko Arakawa
Nov 7, 2012·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Slawomir SekLuis Echegoyen
Aug 3, 2010·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Magdalena Gebala, Wolfgang Schuhmann
Jan 31, 2012·Analytica Chimica Acta·Shiho TokonamiTsutomu Nagaoka
Sep 29, 2006·The Journal of Physical Chemistry. B·Slawomir SekElwira Maicka
Oct 8, 2008·Analytical Chemistry·Shiho TokonamiTsutomu Nagaoka
Jul 27, 2021·Journal of the American Chemical Society·Adela NanoJacqueline K Barton
Aug 21, 2009·The Journal of Physical Chemistry. B·Amit PaulDavid H Waldeck
Jun 5, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Ariel L FurstJacqueline K Barton
Apr 25, 2017·Journal of the American Chemical Society·Edward BeallDavid H Waldeck

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.