In situ Enabling Approaches for Tissue Regeneration: Current Challenges and New Developments

Frontiers in Bioengineering and Biotechnology
Juliana R DiasAna L Oliveira

Abstract

In situ tissue regeneration can be defined as the implantation of tissue-specific biomaterials (by itself or in combination with cells and/or biomolecules) at the tissue defect, taking advantage of the surrounding microenvironment as a natural bioreactor. Up to now, the structures used were based on particles or gels. However, with the technological progress, the materials' manipulation and processing has become possible, mimicking the damaged tissue directly at the defect site. This paper presents a comprehensive review of current and advanced in situ strategies for tissue regeneration. Recent advances to put in practice the in situ regeneration concept have been mainly focused on bioinks and bioprinting techniques rather than the combination of different technologies to make the real in situ regeneration. The limitation of conventional approaches (e.g., stem cell recruitment) and their poor ability to mimic native tissue are discussed. Moreover, the way of advanced strategies such as 3D/4D bioprinting and hybrid approaches may contribute to overcome the limitations of conventional strategies are highlighted. Finally, the future trends and main research challenges of in situ enabling approaches are discussed considering in vit...Continue Reading

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Citations

May 6, 2021·Advanced Healthcare Materials·Susan BabuLaura De Laporte
May 25, 2021·Advanced Science·Assaf Shapira, Tal Dvir
Aug 3, 2021·Cell Regeneration·Nicole Andréa Corbellini HenckesElizabeth Obino Cirne-Lima
Jul 3, 2021·Tissue Engineering. Part B, Reviews·Nureddin AshammakhiEdward J Caterson

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Methods Mentioned

BETA
bioprinting
biograft
Fluorescence microscopy
bioprinter

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