In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution

Mechanisms of Ageing and Development
Alexandra BarboutiVassilis G Gorgoulis

Abstract

Cellular senescence, an age-related process in response to damage and stress, also occurs during normal development and adult life. The thymus is a central lymphoepithelial organ of the immune system that exhibits age-related changes termed thymic involution. Since the mechanisms regulating thymic involution are still not well elucidated, we questioned whether cellular senescence is implicated in this process. We demonstrate, for the first time in situ, that cellular senescence occurs during human thymic involution using SenTraGor™, a novel chemical compound that is applicable in archival tissue material, providing thus further insights in thymus histophysiology.

Citations

Sep 29, 2018·International Journal of Molecular Sciences·Marios KritsilisDimitrios Papadopoulos
Mar 3, 2020·Frontiers in Cellular Neuroscience·Carmen Martínez-Cué, Noemí Rueda
Feb 25, 2020·Oxidative Medicine and Cellular Longevity·Alexandra BarboutiPanagiotis Kanavaros
Jul 23, 2020·Frontiers in Cellular Neuroscience·Dimitrios PapadopoulosRichard S Nicholas
Jan 14, 2021·Cellular and Molecular Life Sciences : CMLS·Camilla S A Davan-WettonTrinidad Montero-Melendez
Sep 30, 2020·Mechanisms of Ageing and Development·Paraskevi N KoutsoudakiVassilis G Gorgoulis
Jul 6, 2020·Mechanisms of Ageing and Development·Avadh KumarDan Ehninger
Mar 23, 2021·Frontiers in Immunology·Manpreet K SemwalAnn V Griffith
Aug 13, 2021·Aging·Vivekananda BudamaguntaDaohong Zhou

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