In situ evidence of pulmonary endothelial activation in patients with granulomatosis with polyangiitis and systemic sclerosis

Lung
Leticia Kawano-DouradoCarmen Sílvia Valente Barbas

Abstract

The aim of this study was to investigate the in situ pulmonary endothelial activation in lung lesions of granulomatosis with polyangiitis (GPA) and systemic sclerosis (SScl). We examined the endothelial expression of ICAM-1, VCAM-1, and E-selectin using immunohistochemistry on formalin-fixed, paraffin-embedded sections of lung lesions of GPA, interstitial lung disease associated with SScl and controls. A significantly enhanced expression of ICAM-1 and E-selectin was observed in GPA and SScl pulmonary endothelium compared to controls. VCAM-1 was more pronouncedly expressed in GPA compared to SScl. These observations are an evidence of in situ pulmonary vascular endothelial activation in lesions of GPA and SScl, adding information to the pathogenic knowledge of both diseases.

References

Dec 1, 1991·Arthritis and Rheumatism·H N ClamanJ R Seibold
May 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H J GundersenA Vesterby
Jan 1, 1993·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·A E KochW G Barr
Feb 1, 1996·Clinical and Experimental Immunology·W J MayetK H Meyer zum Büschenfelde
Aug 1, 1997·British Journal of Rheumatology·M De BandtC Pasquier
Nov 30, 2006·Nature Clinical Practice. Rheumatology·Cees G M KallenbergCoen A Stegeman
Dec 13, 2007·Respiration; International Review of Thoracic Diseases·Erika Franco de CarvalhoVera Luiza Capelozzi
Jun 25, 2008·Journal of Clinical Immunology·P ArrizabalagaC Ascaso
Nov 26, 2010·Annual Review of Pathology·Tamiko R KatsumotoM Kari Connolly
Mar 7, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sara TognarelliSophie Caillat-Zucman

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Citations

Oct 19, 2016·Current Opinion in Rheumatology·Rosaria TalaricoMarta Mosca

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