In situ expression of 15 kDa interferon alpha responsive gene in the developing tooth germ of the mouse lower first molar.

Journal of Molecular Histology
Merina AkhterHidetaka Sakai

Abstract

We previously performed cDNA subtraction between the mouse mandibles at embryonic day 10.5 (E10.5) and E12.0 to make a profile of the regulator genes for odontogenesis. Fifteen kDa interferon alpha responsive gene (Ifrg15) is one of several highly-expressed genes in the E12.0 mandible. The current study examined the precise expression patterns of Ifrg15 mRNA in the mouse mandibular first molar by in situ hybridization to evaluate the possible functional roles of this gene in odontogenesis. Ifrg15 mRNA was expressed in the epithelial and mesenchymal tissues of the mandible at E10.5 and E12.0. The Ifrg15 in situ signal was detected in the epithelial bud and the surrounding mesenchyme at E14.0, and was present in the enamel organ including the primary enamel knot, and in the underlying mesenchyme at E15.0. The in situ signal was restricted in the inner and outer enamel epithelia and the stratum intermedium at E16.0. The signal of Ifrg15 mRNA was further restricted to the inner enamel epithelium and the adjacent stratum intermedium at E17.0 and E18.0. Consequently, the expression of Ifrg15 mRNA was localized in the ameloblasts and odontoblasts at postnatal days 1.0 to 3.0. However, the in situ signal was markedly weaker than at the...Continue Reading

References

Jan 1, 1995·Connective Tissue Research·I ThesleffT Aberg
Jun 1, 1995·Molecular Reproduction and Development·E RiegoJ de la Fuente
Oct 1, 1994·Experimental Cell Research·P Duc-GoiranJ Doly
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·S D DerR H Silverman
Mar 30, 2001·The Journal of Biological Chemistry·A M Gamero, A C Larner
Apr 5, 2002·The Histochemical Journal·H YamazaH Sakai
Sep 10, 2002·Nature Genetics·Shinji KondoJeffrey C Murray
Feb 18, 2004·The Journal of Reproduction and Development·Masashi TakahashiAkira Okano
May 3, 2005·Nature Reviews. Immunology·Leonidas C Platanias
Sep 1, 2005·Histochemistry and Cell Biology·Merina AkhterHidetaka Sakai
Oct 26, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alexandra S KnightMichael J Dixon
Dec 27, 2005·Bone·Ieyoshi KobayashiHidetaka Sakai
Jul 14, 2006·American Journal of Medical Genetics. Part a·Irma Thesleff
Sep 19, 2006·Immunity·Daniel B Stetson, Ruslan Medzhitov
Jun 15, 2007·The Journal of Biological Chemistry·Ming XieHidetaka Sakai
Jan 1, 2010·Journal of Molecular Histology·Ming XieHidetaka Sakai

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Citations

Oct 12, 2012·Histochemistry and Cell Biology·Yukiko F OokumaHidetaka Sakai
Mar 5, 2015·International Journal of Molecular Medicine·Hirotaka SomeyaTamotsu Kiyoshima
Feb 8, 2019·The Journal of Dairy Research·Hossein Naeemipour YounesiPeter Løvendahl

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