In situ Expression of CD40 and CD40 ligand in psoriasis

Dermatology : International Journal for Clinical and Investigative Dermatology
Yukinori Ohta, Yuko Hamada

Abstract

The interaction between CD40 and CD40 ligand (CD40L) provides a signal that contributes to the initiation of cellular immune responses. However, little information on the in vivo expression of CD40 and CD40L in cutaneous inflammation has been reported. To investigate the potential role of CD40-mediated signals in the pathogenesis of psoriasis. In situ CD40 and CD40L expression was examined immunohistochemically in different stages of psoriatic lesions: fully developed and initial pinpoint. In normal skin, faintly positive immunoreactivity for CD40 was seen in the basal keratinocytes and dermal endothelial cells. These showed almost the same intensity as that seen in psoriatic lesional skin. In the dermal infiltrates of psoriatic lesions, CD40 was intensely expressed and some of these positive cells appeared to be dendritic in shape. Whereas CD40 expression was observed almost in all specimens of psoriatic lesions, the expression of CD40L was predominantly detected in the initial pinpoint lesions of psoriasis. These seemed to be distributed close to CD40-positive cells. These results suggested that CD40L-triggered signals could be involved in the early stage of psoriatic lesion formation.

Citations

Jul 29, 2008·Diabetologia·D KleinR L Pastori
Feb 3, 2007·Cancer Immunology, Immunotherapy : CII·Nicolae-Costin DiaconuIlkka T Harvima
Aug 11, 2005·Oncogene·Amanda J BaxendaleAristides G Eliopoulos
Nov 24, 2011·Clinical & Developmental Immunology·Nada AlaaeddineWalid Mourad
Jun 10, 2014·The Journal of Allergy and Clinical Immunology·Elisabetta VolpeVassili Soumelis
Sep 15, 2006·Genes and Immunity·A K StoeckmanE J Peterson
Jan 22, 2015·Arthritis Research & Therapy·Sabrina CeerazRandolph J Noelle
Jul 15, 2009·Seminars in Immunology·Anna L PetersGail A Bishop
May 17, 2006·The Journal of Investigative Dermatology·Jan P Dutz
Jun 20, 2014·The Journal of Investigative Dermatology·Bart TummersJudith M Boer
Jul 23, 2011·The British Journal of Dermatology·A W ArmstrongS V Voyles
Jul 3, 2015·Biochemical and Biophysical Research Communications·Kristina Seibold, Martin Ehrenschwender
Aug 29, 2006·Diabetes·Florencia M Barbé-TuanaRicardo L Pastori
Aug 18, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J LuJ Zheng
Nov 22, 2017·Scientific Reports·Archana BajpaiHiroaki Kitano
May 11, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chanachai SaeleeTewin Tencomnao
Oct 6, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·Maki OzawaHachiro Tagami
Oct 27, 2009·Platelets·Gülsüm Emel PamukMuzaffer Demir
Aug 14, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amanda K HuberYaron Tomer
Oct 1, 2019·Journal of Autoimmunity·Chuan HuangZhe-Xiong Lian

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