In situ formation of hydrogels as vitreous substitutes: Viscoelastic comparison to porcine vitreous

Journal of Biomedical Materials Research. Part a
Katelyn E SwindleNathan Ravi

Abstract

The human vitreous is a gelatinous substance predominantly composed of water (97-99%). Vitreous substitutes are needed for treatment of retinal detachments by reapproximating the retina to the back of the eye, or during vitrectomies for maintenance of ocular volume. None of the current substitutes can be used long-term due to their short retention time, toxicity, or complications such as glaucoma or cataracts. In addition, all of the current compounds have a specific gravity less than water and so are not appropriate for inferior retinal detachments. The viscoelastic properties of the porcine vitreous were analyzed to develop a model for ideal substitutes. Synthetic polymers that form hydrogels in situ were researched for the development of artificial vitreous. In this study, the physical, mechanical, and optical properties of four self-gelling polyacrylamide copolymeric hydrogels were determined and compared with those of the porcine vitreous. The 2% formulation of high crosslink density, hydrophobically modified hydrogel most closely mimicked the porcine vitreous. The viscoelastic properties of hydrogels capable of being formed in situ were compared to those of the porcine vitreous to determine their efficacy as vitreous subs...Continue Reading

References

Oct 1, 1976·Experimental Eye Research·F A Bettelheim, T J Wang
Jan 1, 1984·Biorheology·M TokitaK Hikichi
Jan 1, 1984·Retina·I M ChanD M Albert
Oct 1, 1994·Journal of Biomaterials Applications·T V ChirilaI J Constable
Jun 26, 2003·Investigative Ophthalmology & Visual Science·Leonoor I LosJohanna M M Hooymans
Jul 11, 2006·Journal of Biomedical Materials Research. Part a·S Suri, R Banerjee

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Citations

Feb 3, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Irene SanchezIvan Fernandez-Bueno
Jun 1, 2010·Biomechanics and Modeling in Mechanobiology·R RepettoE Colangeli
Feb 12, 2011·Journal of Biomaterials Science. Polymer Edition·Stefania LamponiAgnese Magnani
May 24, 2011·Survey of Ophthalmology·Teri T KleinbergShalesh Kaushal
Nov 3, 2010·Journal of Biomechanics·Pooria Sharif-KashaniH Pirouz Kavehpour
Nov 28, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Alexandra PartenhauserAndreas Bernkop-Schnürch
Jul 14, 2010·Macromolecular Bioscience·Li SongSiquan Zhu
May 14, 2011·NMR in Biomedicine·Marco PiccirelliRoger Luechinger
Aug 1, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Andreia de Araujo Morandim-GiannettiPatrícia Alessandra Bersanetti
Aug 26, 2014·BioMed Research International·Krystyna IsakovaMario R Romano
May 31, 2014·BioMed Research International·Simone DonatiClaudio Azzolini
Dec 2, 2008·Experimental Eye Research·Matthew A ReillyNathan Ravi
Mar 29, 2011·Veterinary Pathology·M M SwindleK S Frazier
Feb 27, 2018·Biomechanics and Modeling in Mechanobiology·J VroonA Elsheikh
Sep 17, 2010·Journal of Biomaterials Science. Polymer Edition·Wen-Yu SuFeng-Huei Lin
Apr 4, 2009·Expert Review of Ophthalmology·William Joseph Foster
Dec 18, 2019·Macromolecular Bioscience·Nguyen K TramKatelyn E Swindle-Reilly
Jul 12, 2019·Translational Vision Science & Technology·André SchulzPeter Szurman
Nov 28, 2015·Eye and Vision·Andrea BonfiglioAlessandro Stocchino
Jan 9, 2019·Frontiers in Bioengineering and Biotechnology·Nguyen K Tram, Katelyn E Swindle-Reilly
Feb 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jing ChangYanbin Huang
Jun 17, 2015·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·S Mariacher, P Szurman
Apr 2, 2019·Frontiers in Bioengineering and Biotechnology·UNKNOWN Frontiers Production Office
Dec 20, 2018·Translational Vision Science & Technology·Mario Rosario RomanoRodolfo Repetto
Dec 16, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Indu YadavNarayan Chandra Mishra
Jan 5, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Irene NepitaAlessandro Stocchino
Jan 7, 2021·Biomacromolecules·Metin KarayilanMatthew L Becker
May 15, 2021·Macromolecular Bioscience·Cristina Mondelo-GarcíaFrancisco J Otero-Espinar
Jun 27, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M GhemameF Mouriaux

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