In-situ forming composite implants for periodontitis treatment: How the formulation determines system performance

International Journal of Pharmaceutics
M P DoF Siepmann

Abstract

Periodontitis is the primary cause of tooth loss in adults and a very wide-spread disease. Recently, composite implants, based on a drug release rate controlling polymer and an adhesive polymer, have been proposed for an efficient local drug treatment. However, the processes involved in implant formation and the control of drug release in these composite systems are complex and the relationships between the systems' composition and the implants' performance are yet unclear. In this study, advanced characterization techniques (e.g., electron paramagnetic resonance, EPR) were applied to better understand the in-situ forming implants based on: (i) different types of poly(lactic-co-glycolic acid) (PLGA) as drug release rate controlling polymers; (ii) hydroxypropyl methylcellulose (HPMC) as adhesive polymer; and (iii) doxycycline or metronidazole as drugs. Interestingly, HPMC addition to shorter chain PLGA slightly slows down drug release, whereas in the case of longer chain PLGA the release rate substantially increases. This opposite impact on drug release was rather surprising, since the only difference in the formulations was the polymer molecular weight of the PLGA. Based on the physico-chemical analyses, the underlying mechanis...Continue Reading

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Citations

Aug 1, 2016·International Journal of Pharmaceutics·Janja MirtičMarianne Hiorth
Nov 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Christopher HernandezAgata A Exner
Mar 30, 2017·Therapeutic Delivery·Christopher Hernandez, Agata A Exner
Jan 26, 2017·Médecine sciences : M/S·Nicolas BlanchemainJuergen Siepmann
Jul 28, 2019·International Journal of Pharmaceutics·C BodeJ Siepmann
May 14, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Setthapong SenaratThawatchai Phaechamud
Aug 8, 2021·Advanced Drug Delivery Reviews·Xiaoyi Wang, Diane J Burgess

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