In situ gelling and mucoadhesive polymers: why do they need each other?

Expert Opinion on Drug Delivery
Forouhe Zahir-JouzdaniAndreas Bernkop-Schnürch

Abstract

Mucosal drug delivery is an attractive route of administration, particularly in overcoming deficits of conventional dosage forms including high first-pass metabolism and poor bioavailability. Fast drainage from the target mucosa, however, represents a major limitation as it prevents sufficient drug absorption. In order to address these problems, mucoadhesive in situ gelling drug delivery systems have been investigated as they facilitate easy application in combination with a longer residence time at the administration site resulting in more desirable therapeutic effects. The present review evaluates the importance of the combination of mucoadhesive and in situ gelling polymers along with mechanisms of in situ gelation and mucoadhesion. In addition, an overview about recent applications in mucosal drug delivery is provided. In situ gelling and mucoadhesive polymers proved to be essential excipients in order to prolong the mucosal residence time of drug delivery systems. Due to this prolonged residence time both local and systemic therapeutic efficacy of numerous drugs can be substantially improved. Depending on the site of administration and the incorporated drug, combinations of different polymers with in situ gelling and mucoa...Continue Reading

References

Feb 1, 1981·Archives of Ophthalmology·M B AbelsonJ H Weston
Oct 31, 1998·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·J CarlforsK Jörnving
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·D A Fancy, T Kodadek
Jun 11, 1999·International Journal of Pharmaceutics·J M BarichelloT Nagai
Sep 24, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M PaulssonK Edsman
May 29, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·S MiyazakiD Attwood
Jul 29, 2000·Drug Development and Industrial Pharmacy·A K SinglaA Singh
Dec 5, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·H R Lin, K C Sung
Apr 9, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·C AtumaL Holm
Dec 18, 2001·Journal of Biomedical Materials Research·Jeong-Sook ParkChong-Kook Kim
Jun 6, 2002·Drug Discovery Today·Piyush GuptaSanjay Garg
Jun 28, 2002·International Journal of Pharmaceutics·Jung Yun ChangChong-Kook Kim
Jul 11, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jung Yun ChangChong-Kook Kim
Mar 15, 2003·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Margit D HornofAndreas Bernkop-Schnürch
Jan 20, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Andreas Bernkop-SchnürchDavide Guggi
Aug 7, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Eve Ruel-Gariépy, Jean-Christophe Leroux
Sep 24, 2005·Advanced Drug Delivery Reviews·Andreas Bernkop-Schnürch
Sep 27, 2005·Advanced Drug Delivery Reviews·Vjera GrabovacAndreas Bernkop-Schnürch
Oct 4, 2005·Advanced Drug Delivery Reviews·Annick Ludwig
Apr 18, 2006·International Journal of Pharmaceutics·Zhidong LiuWeisan Pan
Sep 21, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Leda Klouda, Antonios G Mikos
Oct 9, 2007·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Noha M ZakiSeham S Abd Elhady
Nov 17, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·P S Rajinikanth, B Mishra
Jun 11, 2008·Biomacromolecules·Ioannis A SogiasVitaliy V Khutoryanskiy
Jun 20, 2008·Journal of Pharmaceutical Sciences·Juliane HombachAndreas Bernkop-Schnürch
Jul 23, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Laura MayolMaria I La Rotonda
Feb 25, 2009·Pharmaceutical Development and Technology·Veena S BelgamwarSanjay J Surana
Aug 25, 2009·Biomaterials·Duangkamon SakloetsakunAndreas Bernkop-Schnürch
Mar 2, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Taís GratieriRenata Fonseca Vianna Lopez
Dec 15, 2010·Biomacromolecules·Laura MayolMaria I La Rotonda
Dec 29, 2010·Macromolecular Bioscience·Vitaliy V Khutoryanskiy
Mar 23, 2011·Journal of Biomaterials Science. Polymer Edition·Hong-Ru LinMing-Hung Ling
Jun 8, 2011·Current Drug Discovery Technologies·Giuseppina SandriCarla Caramella
Nov 29, 2011·Biomaterials·Javed IqbalAndreas Bernkop-Schnürch
Feb 4, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lisbeth Illum
Feb 14, 2012·Drug Development and Industrial Pharmacy·Fabian HintzenAndreas Bernkop-Schnürch

❮ Previous
Next ❯

Citations

Sep 11, 2019·Pharmaceutics·Eliana B SoutoElena Sánchez-López
Mar 28, 2020·Pharmaceutical Research·Joana GonçalvesAna Fortuna
Jan 15, 2021·Advances in Colloid and Interface Science·Brunella GrassiriAndreas Bernkop-Schnürch
Apr 19, 2021·Journal of Pharmaceutical Sciences·Debora CaricatoStefano Giovagnoli
May 21, 2021·Advanced Materials·Giorgio ContaJun Chen
Jun 3, 2021·International Journal of Molecular Sciences·Maria BialikEwa Oledzka
Nov 19, 2021·Expert Opinion on Biological Therapy·Parisa GhandforoushanGorka Orive

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques
Esra BalogluAndreas Bernkop-Schnürch
PDA Journal of Pharmaceutical Science and Technology
Dattatraya Manohar ShinkarChitral Mallikarjuna Setty
Journal of Advanced Pharmaceutical Technology & Research
Bindu M BoddupalliDavid Banji
Handbook of Experimental Pharmacology
Juliane Hombach, Andreas Bernkop-Schnürch
© 2022 Meta ULC. All rights reserved