In Situ Growth of Mesoporous Silica with Drugs on Titanium Surface and Its Biomedical Applications

ACS Applied Materials & Interfaces
Mimi WanJian Shen

Abstract

Mesoporous silica has been developed for the modification of titanium surfaces that are used as implant materials. Yet, the traditional modification methods failed to effectively construct mesoporous silica on the titanium surface evenly and firmly, in which the interaction between mesoporous silica and titanium was mainly physical. Here, in situ growth of mesoporous silica on a titanium surface was performed using a simple evaporation-induced self-assembly strategy. Meantime, in situ introduction of drugs (heparin and vancomycin) to mesoporous silica was also adopted to improve the drug-loading amount. Both the above-mentioned processes were completed at the same time. Transmission electron microscopy, N2 adsorption-desorption isotherms, Fourier transform infrared spectroscopy, scanning electron microscopy, and water contact angle measurements were used to characterize the structure of the mesoporous silica film. Results indicated that the mesoporous silica film that in situ grew on the titanium surface was smooth, thin, transparent, and stable. Cytotoxicity, proliferation performance of osteoblast cells, and in vitro and in vivo studies of the antibacterial activity of the coating were tested. This is the first study to modif...Continue Reading

References

May 7, 1998·Journal of Biomedical Materials Research·G D JayC J Cha
Jun 8, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·C P Price, H Finney
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·J M Gomez-VegaA Hozumi
Dec 21, 2005·Biomaterials·Davide CampocciaCarla Renata Arciola
Mar 1, 2007·Arthritis and Rheumatism·Tannin A SchmidtRobert L Sah
Jul 25, 2009·Biomaterials·Isabel Izquierdo-BarbaMartin Malmsten
Jul 29, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Lingzhou ZhaoZhifen Wu
Mar 3, 2010·Clinical Orthopaedics and Related Research·S Mehdi JafariJavad Parvizi
Aug 2, 2012·ACS Applied Materials & Interfaces·Mi Mi WanJian Hua Zhu
Oct 31, 2012·The Journal of Bone and Joint Surgery. British Volume·S OussedikF S Haddad
Mar 24, 2015·ACS Applied Materials & Interfaces·Martina AbrigoSally L McArthur
Mar 2, 2016·ACS Applied Materials & Interfaces·Meng HeHuiming Wang
Mar 22, 2016·Chemistry : a European Journal·Mi Mi WanJian Hua Zhu
Oct 14, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaobo WangJian Shen
Jan 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wen Juan QianJian Hua Zhu
Jan 28, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lang MaChangsheng Zhao

❮ Previous
Next ❯

Citations

Sep 28, 2018·Journal of Biomedical Materials Research. Part a·Ju LiuKaiyong Cai
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qi WangChun Mao
Apr 30, 2019·Small·Andrea BernardosRamón Martínez-Máñez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.