In situ hematopoiesis: a regulator of TH2 cytokine-mediated immunity and inflammation at mucosal surfaces

Mucosal Immunology
C C K HuiMark C Siracusa

Abstract

Hematopoiesis refers to the development of blood cells in the body through the differentiation of pluripotent stem cells. Although hematopoiesis is a multifocal process during embryonic development, under homeostatic conditions it occurs exclusively within the bone marrow. There, a limited number of hematopoietic stem cells differentiate into a rapidly proliferating population of lineage-restricted progenitors that serve to replenish circulating blood cells. However, emerging reports now suggest that under inflammatory conditions, alterations in hematopoiesis that occur outside of the bone marrow appear to constitute a conserved mechanism of innate immunity. Moreover, recent reports have identified previously unappreciated pathways that regulate the egress of hematopoietic progenitor cells from the bone marrow, alter their activation status, and skew their developmental potential. These studies suggest that progenitor cells contribute to inflammatory response by undergoing in situ hematopoiesis (ISH). In this review, we highlight the differences between homeostatic hematopoiesis, which occurs in the bone marrow, and ISH, which occurs at mucosal surfaces. Further, we highlight factors produced at local sites of inflammation that...Continue Reading

References

May 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P G GibsonF E Hargreave
Jan 1, 1990·Annual Review of Biochemistry·K I AraiT Yokota
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D Metcalf
Sep 1, 1985·The Journal of Allergy and Clinical Immunology·J A DenburgJ Bienenstock
Dec 1, 1994·The Journal of Allergy and Clinical Immunology·J A DenburgP O'Byrne
Jan 1, 1996·American Journal of Respiratory Cell and Molecular Biology·G Z Retsch-BogartA D Stiles
Nov 1, 1996·American Journal of Respiratory Cell and Molecular Biology·R SehmiJ A Denburg
Feb 17, 1997·The Journal of Experimental Medicine·M E RothenbergP Leder
Feb 7, 1997·Cell·S J MorrisonD J Anderson
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·L J WoodP M O'Byrne
Jul 3, 1998·American Journal of Respiratory Cell and Molecular Biology·G M GauvreauJ A Denburg
Dec 31, 1998·American Journal of Respiratory Cell and Molecular Biology·D S RobinsonQ Hamid
Feb 25, 1999·American Journal of Respiratory Cell and Molecular Biology·Y K KimJ A Denburg
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·G M GauvreauP M O'Byrne
Jan 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L CameronQ Hamid
Sep 8, 2001·Nature Immunology·M SchnareR Medzhitov
Nov 13, 2001·American Journal of Respiratory and Critical Care Medicine·R G StirlingK F Chung
Dec 1, 2001·Science·D E WrightI L Weissman
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiroko SaitoJudah A Denburg
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen D HurstRobert L Coffman
Jul 4, 2002·International Immunology·Tsuneyasu KaishoShizuo Akira
Oct 18, 2002·Experimental Hematology·Erin DrewKelly M McNagny
Jan 4, 2003·Current Topics in Developmental Biology·Jenna L Galloway, Leonard I Zon
Sep 27, 2003·Blood·Mark J OsbornKim-Sue R S Tudor
Oct 18, 2003·The Journal of Allergy and Clinical Immunology·Margarita Martinez-Moczygemba, David P Huston
Dec 6, 2003·American Journal of Respiratory and Critical Care Medicine·Sandra C DormanPaul M O'Byrne
Dec 31, 2003·The Journal of Allergy and Clinical Immunology·Jennifer K GarrettMarc E Rothenberg
Jan 8, 2005·The Journal of Allergy and Clinical Immunology·David S SouthamRoma Sehmi
Jan 15, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S SergejevaT Pullerits
Sep 6, 2005·Nature Immunology·Baohua ZhouSteven F Ziegler
Mar 23, 2006·Annual Review of Immunology·Marc E Rothenberg, Simon P Hogan
May 25, 2006·Immunologic Research·Sebastian George Barton Furness, Kelly McNagny

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Citations

Dec 3, 2015·Mucosal Immunology·M WeitnauerA H Dalpke
Mar 3, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D TworekJ A Denburg
Feb 6, 2018·Current Pharmacology Reports·Everett K HenryMark C Siracusa
Sep 2, 2017·American Journal of Respiratory and Critical Care Medicine·Elizabeth A KellyNizar N Jarjour
May 11, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Nichole A Broderick
Jan 10, 2020·Physiological Reviews·Anuradha RaySally E Wenzel
Apr 20, 2018·Journal of Leukocyte Biology·Paneez KhouryAmy D Klion
Apr 16, 2018·Journal of Leukocyte Biology·Hiam Abdala-ValenciaSergejs Berdnikovs
May 30, 2020·International Journal of Molecular Sciences·Emma BobergMadeleine Rådinger
Mar 6, 2021·The Journal of Experimental Medicine·Takao SudoMasaru Ishii
Mar 28, 2021·Current Opinion in Immunology·Matthew J CamioloAnuradha Ray

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