PMID: 8943053Nov 26, 1996Paper

In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain

Proceedings of the National Academy of Sciences of the United States of America
K PageB T Hyman

Abstract

Presenilin-1 (PS-1) gene mutations are responsible for the majority of the early onset familial forms of Alzheimer disease (AD). Neither PS-1's anatomic distribution in brain nor expression in AD have been reported. Using in situ hybridization in the rat forebrain, we show that PS-1 mRNA expression is primarily in cortical and hippocampal neurons, with less expression in subcortical structures, in a regional pattern similar to APP695. Excitotoxic lesions lead to loss of PS-1 signal. A neuronal pattern of expression of PS-1 mRNA was also observed in the human hippocampal formation. AD and control levels did not differ. PS-1 is expressed in brain areas vulnerable to AD changes more so than in areas spared in AD; however, PS-1 expression is not sufficient to mark vulnerable regions. Collectively, these data suggest that the neuropathogenic process consequent to PS-1 mutations begins in neuronal cell populations.

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Citations

Oct 31, 2002·Human Psychopharmacology·Kurt Heininger
May 3, 2011·Nature Neuroscience·Adam W BeroDavid M Holtzman
Apr 25, 1997·The Journal of Biological Chemistry·T W KimR E Tanzi
Jul 31, 1998·Reviews in the Neurosciences·P L McGeerE G McGeer
Aug 21, 2010·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Joseph P SteinerMichael O Poulter

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