PMID: 7547633Aug 1, 1995Paper

In situ hybridization analysis of the Y chromosome in gonadoblastoma

Genes, Chromosomes & Cancer
R SultanaC M Disteche

Abstract

Gonadoblastoma is a rare tumor arising in the streak gonads of about 30% of 46,XY sex-reversed females. Because gonadoblastoma develops only in patients who have Y-chromosome material and dysgenetic gonads, it has been hypothesized that positive expression of a gene (or genes) on the Y chromosome (GBY) is involved in the etiology of the tumor. To examine the Y chromosome directly in tumors, we performed nonisotopic in situ hybridization of a biotin-labeled Y-specific probe for the DYZI locus on formalin-fixed, paraffin-embedded sections of tumor samples from four different patients. After hybridization to DYZI, the Y chromosome was found to be present in all gonadoblastoma foci in the four patients studied, and the gonadoblastoma foci showed an average of 85% cell nuclei positive for the Y chromosome on tissue sections. Normal male and female control tissues showed an average of 78% and 0% positive nuclei, respectively. One patient with bilateral gonadoblastoma had previously been shown to be mosaic, with a 45,X/46,XY karyotype in lymphocytes, skin fibroblasts, and cultures from both gonads. Examination of sections of this patient's gonads showed 79% positive nuclei within the gonadoblastoma foci, whereas the nontumor stromal t...Continue Reading

References

Nov 1, 1976·American Journal of Obstetrics and Gynecology·H O WilliamsonH R Pratt-Thomas
Feb 11, 1976·American Journal of Obstetrics and Gynecology·M ManuelH W Jones
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C M DistecheM Fellous
Jan 1, 1987·Cytogenetics and Cell Genetics·C D BloomfieldH van den Berghe
Apr 1, 1987·Cancer Genetics and Cytogenetics·M S Verp, J L Simpson
Oct 15, 1986·International Journal of Cancer. Journal International Du Cancer·B DutrillauxM G Seureau
Apr 1, 1987·Cancer Genetics and Cytogenetics·B J BatemanJ O Armitage
Jul 1, 1985·Cancer Genetics and Cytogenetics·R I HolmesE J Freireich
Jun 1, 1970·Cancer·R E Scully
Jan 1, 1993·Human Mutation·J R Hawkins

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Citations

Aug 8, 2002·Cancer Genetics and Cytogenetics·Cristina MorerioClaudio Panarello
Jun 5, 2003·Cancer Genetics and Cytogenetics·Sarantis LivadasCatherine Dacou-Voutetakis
Aug 25, 1999·Cancer Genetics and Cytogenetics·S UeharaA Yajima
Jan 29, 1999·Endocrinology and Metabolism Clinics of North America·G L Warne, J D Zajac
Jun 23, 2011·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Mélanie Beaulieu BergeronPierre Brochu
May 10, 2005·American Journal of Medical Genetics. Part a·Laura MazzantiEmanuele Cacciari
Sep 25, 2004·American Journal of Medical Genetics. Part a·Alison KentMartin Silink
Jun 6, 2007·Clinical Endocrinology·Martine CoolsLeendert H J Looijenga
Jul 5, 2013·American Journal of Medical Genetics. Part a·Shane C QuinonezCatherine E Keegan
Mar 26, 1999·American Journal of Human Genetics·Y F Lau
Jan 1, 2006·Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology·Ikuko TakahashiYukihiro Hasegawa
Apr 14, 2009·Fertility and Sterility·Pernille Bach JorgensenJens Fedder
Dec 30, 1999·Journal of Pediatric Endocrinology & Metabolism : JPEM·D DamianiN Setian
Jun 8, 2018·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·Megumi HatanoYukihiro Hasegawa
Apr 6, 2002·Circulation Research·Michael A LaflammeCharles E Murry

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