PMID: 8595371Nov 1, 1995Paper

In situ hybridization of fluorescent probes on chromosomes, nuclei or stretched DNA: applications in physical mapping and characterization of genomic rearrangements

Cellular and Molecular Biology
C Desmaze, A Aurias

Abstract

During the last few years, various technologies and applications of fluorescence in situ hybridization (FISH) have been developed. Hybridization on nuclei allows an increase in the resolution of the technique. It also permits the characterization of some chromosomal abnormalities such as trisomies, monosomies or translocations in pathological cells when it is difficult to obtain metaphases. Recently, several methods which extend the chromatin or the DNA molecules have been developed. Such a support increases the FISH resolution to the molecular level.

Related Concepts

Related Feeds

22q11 Deletion Syndrome

22q11.2 deletion syndrome, also known as DiGeorge syndrome, is a congenital disorder caused by a partial deletion of chromosome 22. Symptoms include heart defects, poor immune system function, a cleft palate, complications related to low levels of calcium in the blood, and delayed development. Discover the latest research on this disease here.

Related Papers

Methods in Molecular Biology
Pulivarthi H RaoVundavalli V Murty
Forum : Trends in Experimental and Clinical Medicine
C Mecucci, R La Starza
Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B
J TchindaJürgen Horst
© 2021 Meta ULC. All rights reserved