In situ hybridization studies of alpha 2-macroglobulin receptor and receptor-associated protein in human prostate carcinoma

The Prostate
T McGarveyM E Stearns

Abstract

We have utilized in situ hybridization and immunocytochemistry techniques to examine the expression of both alpha 2-macroglobulin (alpha 2-MR) and the 39 kDa receptor-associated protein (RAP) in 8 benign (BPH) and 34 malignant human prostate tissues, including 4 metastases. The levels of alpha 2-MR mRNA expression (but not RAP) increased significantly in high Gleason score carcinomas ( > 8) and in metastatic lesions, suggesting that alpha 2-MR expression is associated with advanced cancer. Semi-quantitative analysis with computer-assisted system analysis (CASA) confirmed this interpretation. This is the first report of alpha 2-MR expression being associated with advanced prostate cancer.

References

Jan 1, 1990·Histochemistry·P KristensenK Danø
May 1, 1990·Journal of Clinical Pathology·M FarquharsonA M McNicol

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Citations

Dec 17, 2014·International Journal of Molecular Sciences·Ling Lin, Kebin Hu
Mar 26, 2014·Pathologie-biologie·H EmonardS Dedieu
Mar 7, 2018·Oncotarget·Camille Boulagnon-RombiStéphane Dedieu
Oct 17, 2013·The American Journal of Pathology·Steven L Gonias, W Marie Campana
Dec 22, 2004·The Prostate·Victor K LinClaus G Roehrborn

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