Abstract
In situ longitudinal (axial) pre-stretch (LPS) plays a fundamental role in the mechanics of the femoropopliteal artery (FPA). It conserves energy during pulsation and prevents buckling of the artery during limb movement. We investigated how LPS is affected by demographics and risk factors, and how these patient characteristics associate with the structural and physiologic features of the FPA. LPS was measured in n=148 fresh human FPAs (14-80 years old). Mechanical properties were characterized with biaxial extension and histopathological characteristics were quantified with Verhoeff-Van Gieson Staining. Constitutive modeling was used to calculate physiological stresses and stretches which were then analyzed in the context of demographics, risk factors and structural characteristics. Age had the strongest negative effect (r=-0.812, p<0.01) on LPS and could alone explain 66% of LPS variability. Male gender, higher body mass index, hypertension, diabetes, coronary artery disease, dyslipidemia and tobacco use had negative effects on LPS, but only the effect of tobacco was not associated with aging. FPAs with less pre-stretch had thicker medial layers, but thinner intramural elastic fibers with less dense and more fragmented externa...Continue Reading
References
Sep 1, 1975·Journal of Biomechanics·R H Cox
Feb 1, 1990·The Journal of Surgical Research·P B DobrinR Mrkvicka
May 1, 1986·Journal of Biomechanical Engineering·C J Chuong, Y C Fung
Jan 1, 1986·Journal of Biomechanics·P B Dobrin
Jul 1, 1970·Circulation Research·P B Dobrin, J M Doyle
Mar 1, 1966·Circulation Research·B M Learoyd, M G Taylor
Dec 1, 1966·Circulation Research·D J Patel, D L Fry
May 4, 2002·Circulation Research·Zane S JacksonB Lowell Langille
Aug 22, 2003·Journal of Biomechanical Engineering·Christian A J Schulze-BauerGerhard A Holzapfel
Sep 1, 2007·Stroke; a Journal of Cerebral Circulation·Søren DalagerErling Falk
Dec 17, 2008·Journal of Biomechanics·J D HumphreyR L Gleason
Dec 14, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Avione Y LeeHai-Chao Han
Nov 30, 2012·Annals of Biomedical Engineering·Hai-Chao HanQi Wen
Jun 1, 2013·Journal of Biomechanical Engineering·Stéphane AvrilSusan M Lessner
Dec 29, 2013·Acta Biomaterialia·Alexey V KamenskiyJason N MacTaggart
Apr 9, 2014·Biomechanics and Modeling in Mechanobiology·Alexey V KamenskiyJason N MacTaggart
May 27, 2014·Journal of Biomechanics·Jason N MacTaggartAlexey V Kamenskiy
Oct 11, 2014·Acta Biomaterialia·Alexey V KamenskiyJason N MacTaggart
Dec 17, 2014·Journal of Vascular Surgery·Alexey V KamenskiyB Timothy Baxter
Jun 23, 2015·Surgery·Alexey KamenskiyJason MacTaggart
Citations
Feb 23, 2018·Annals of Biomedical Engineering·Kaspars MaleckisAlexey Kamenskiy
Jan 27, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Alexey KamenskiyJason MacTaggart
Oct 27, 2018·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Eric ShurtleffKamal Gupta
Apr 25, 2019·Journal of Biomechanical Engineering·Nir Emuna, David Durban
Sep 7, 2019·Biomechanics and Modeling in Mechanobiology·Anastasia DesyatovaAlexey Kamenskiy
Jul 27, 2018·Transplantation Direct·Sara M LewinNeil Mehta
Aug 18, 2017·Biomechanics and Modeling in Mechanobiology·Anastasia DesyatovaAlexey Kamenskiy
Nov 22, 2016·Biomechanics and Modeling in Mechanobiology·Anastasia DesyatovaAlexey Kamenskiy
Oct 25, 2016·Biomechanics and Modeling in Mechanobiology·Alexey KamenskiyJason MacTaggart
Mar 24, 2017·Journal of the Royal Society, Interface·Anastasia DesyatovaAlexey Kamenskiy
May 10, 2019·Biomechanics and Modeling in Mechanobiology·Majid JadidiAlexey Kamenskiy
Mar 27, 2018·Annals of Surgery·Jason MacTaggartAlexey Kamenskiy
Aug 24, 2018·Journal of the Royal Society, Interface·Anastasia DesyatovaAlexey Kamenskiy
Dec 7, 2020·Acta Biomaterialia·Majid JadidiGerhard A Holzapfel
Nov 24, 2020·Acta Biomaterialia·Majid JadidiAlexey Kamenskiy
Apr 1, 2019·Acta Biomaterialia·Eric AnttilaAlexey Kamenskiy
Jul 30, 2021·Journal of Biomechanics·Yundi FengYunlong Huo
Nov 1, 2020·Acta Biomaterialia·Majid JadidiAlexey Kamenskiy