In situ low-immunogenic albumin-conjugating-corona guiding nanoparticles for tumor-targeting chemotherapy

Biomaterials Science
Zhenbao LiJin Sun

Abstract

Nanoparticles (NPs) are unavoidably covered by a layer of immunogenic proteins upon injection into blood, such as immunoglobins and complements, which buries the active-targeting ligands and triggers the rapid clearance of NPs by the mononuclear phagocytic system. Low antifouling polyethylene glycol is used to inhibit the formation of the immunogenic corona but it leads to poor cellular uptake and the immunogen-related accelerated blood clearance (ABC) phenomenon in multiple administrations. Here, we develop surface maleimide-modified NPs that covalently conjugate in vivo plasma albumin in its corona upon exposure to blood. The in situ recruited low-immunogenic albumin-enriching corona is capable of protecting maleimide-decorated NPs from phagocytosis in the bloodstream, preventing the ABC phenomenon in the second administration, facilitating NP accumulation in the tumor site/cells by the passive EPR effect and albumin receptor-mediated active targeting, and finally improving the antitumor activity. Such findings suggest that the facile strategy, based on the in situ anchored albumin-enriching corona, is efficient at enabling maleimide-decorated NPs to acquire stealth and tumor-targeting ability.

References

Jun 27, 2007·Angewandte Chemie·Tommy CedervallKenneth A Dawson
Sep 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Martin LundqvistKenneth A Dawson
Feb 4, 2011·Journal of the American Chemical Society·Marco P MonopoliKenneth A Dawson
May 10, 2012·Accounts of Chemical Research·Lígia C Gomes-da-SilvaJoão N Moreira
Jul 11, 2012·The Journal of Physical Chemistry. B·Candace C Fleischer, Christine K Payne
Sep 24, 2013·Nature Nanotechnology·Stefan TenzerRoland H Stauber
Mar 19, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Felix Kratz
Jul 12, 2014·Accounts of Chemical Research·Candace C Fleischer, Christine K Payne
Mar 31, 2015·Nature Nanotechnology·Philip M KellyKenneth A Dawson
Jun 10, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Malin BernJan Terje Andersen
Sep 18, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Giulio CaraccioloAldo Laganà
Apr 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Hong-Jun LiJun Wang
Dec 23, 2016·Journal of the American Chemical Society·Luciana M HerdaKenneth A Dawson
Dec 6, 2017·ACS Nano·Pu Chun KeFrank Caruso

❮ Previous
Next ❯

Citations

Jun 4, 2019·Biomaterials Science·Jose D DelgadoJoseph B Schlenoff
Sep 25, 2019·Current Pharmaceutical Biotechnology·Tianzhong LiMengsu Yang
Apr 21, 2020·Frontiers in Bioengineering and Biotechnology·Riccardo RampadoMarco Agostini
Jun 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chao TaoDong-An Wang
Oct 30, 2020·Drug Delivery·Xue JiangLongfa Kou
Apr 10, 2021·Biomaterials·Yachao ZhangShuangying Gui
Dec 24, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Xihui GaoChangyou Zhan
May 29, 2021·Acta Biomaterialia·Hanmei LiQiang Peng

❮ Previous
Next ❯

Methods Mentioned

BETA
silica column chromatography
NMR
transmission electron microscopy
X-ray
dynamic light scattering
protein assay
flow cytometry
ELISA
fluorescence imaging
xenograft

Software Mentioned

DAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.