In situ methotrexate injection for treatment of recurrent endometriotic cysts

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Aubert AgostiniBernard Blanc

Abstract

Ovarian endometrioma recurrence is frequent. Conventional treatment of ovarian endometrioma is by surgical cystectomy. We proposed an alternative medical treatment for recurrent ovarian endometrioma: cyst aspiration followed by in situ methotrexate injection. From January 2002 to May 2003, 14 patients with recurrent homolateral ovarian endometrioma underwent transvaginal ultrasound guided cyst puncture and aspiration followed by methotrexate injection, whilst under general anasthesia. Recurrence rate during follow up was evaluated. No complication was reported. After a mean follow up of 20+/-5 month (min: 13, max: 29), four recurrences were diagnosed (28.6%). Two asymptomatic recurrences were not treated and two painful recurrences underwent a second cyst drainage with methotrexate injection. In situ methotrexate injection is a simple, effective and an interesting alternative to surgical treatment in women with recurrent homolateral ovarian endometrioma.

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Citations

Nov 12, 2013·Journal de gynécologie, obstétrique et biologie de la reproduction·B BorgheseC Chapron
Oct 25, 2008·Human Reproduction·Paolo VercelliniPier Giorgio Crosignani
Jan 14, 2011·Dermatology : International Journal for Clinical and Investigative Dermatology·Hayriye SarıcaogluHakan Turan
Oct 25, 2011·Reproductive Biomedicine Online·Chiara Perono BiacchiardiAlberto Revelli
Apr 3, 2016·Reproductive Biomedicine Online·Giuseppe BenagianoIvo Brosens
Apr 4, 2016·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Fernanda C GonçalvesSergio Podgaec
Nov 4, 2015·Archives of Gynecology and Obstetrics·Ming-Jun ShaoXiao-Jiu Xu
Sep 13, 2016·Expert Opinion on Pharmacotherapy·Giuseppe BenagianoIvo Brosens
May 11, 2021·Taiwanese Journal of Obstetrics & Gynecology·Lulu HuangT'sang-T'ang Hsieh

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