PMID: 11920582Mar 29, 2002Paper

In situ repair of cyclobutane pyrimidine dimers in skin and melanocytic nevi of cutaneous melanoma patients

International Journal of Cancer. Journal International Du Cancer
Chunyan ZhaoKari Hemminki

Abstract

The development of cutaneous malignant melanoma (CMM) and its precursor lesions, melanocytic nevi, has been linked to sun exposure. Cyclobutane pyrimidine dimers (CPDs) are the majority of DNA lesions induced by sun exposure. In our study, we investigated if CMM patients have impaired ability to repair CPDs in skin as well as in melanocytic nevi. The repair kinetics were followed up to 3 weeks after exposure to 40 mJ/cm(2) of solar simulating radiation. Altogether 12 CMM patients and 10 healthy controls were included in our study. Buttock skin biopsies were taken at 0 hr, 48 hr and 3 weeks after UV exposure, whereas melanocytic nevi and surrounding skin biopsies were taken only at 0 hr and 3 weeks. The CPD levels were measured by a (32)P-postlabeling method. The results showed that the repair rate of CPDs in neither the skin nor the nevi was significantly different between the CMM patients and the control group. For both groups, the repair rate of TT = C was faster than that for TT = T. The important finding is that about 10% of the initial TT = T damage remained unrepaired after 3 weeks, and was detectable in normal epidermis as well as in nevi of all subjects. We also found that the amount of TT = C and TT = T at 0 hr in nevi...Continue Reading

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Citations

Sep 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stéphane MouretThierry Douki
Dec 21, 2002·International Journal of Cancer. Journal International Du Cancer·Rajiv KumarKari Hemminki
Sep 17, 2002·The Journal of Investigative Dermatology·Kari Hemminki, Erna Snellman
Jan 25, 2003·The Journal of Investigative Dermatology·Kari HemminkiKamila Czene
Mar 11, 2004·The Journal of Investigative Dermatology·Rajiv KumarKari Hemminki
Jul 15, 2015·Journal of Photochemistry and Photobiology. B, Biology·D BacquevilleH Duplan
Aug 10, 2011·Journal of Immunological Methods·Onno ten BergeHuib van Weelden
Mar 18, 2003·International Journal of Cancer. Journal International Du Cancer·Kari HemminkiKamila Czene
Feb 4, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·V PiccoloG Argenziano
Sep 5, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Dan SegerbäckKari Hemminki

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