In situ self-spray coating system that can uniformly disperse a poorly water-soluble H2 S donor on the colorectal surface to treat inflammatory bowel diseases

Biomaterials
Wei-Chih LinHsing-Wen Sung

Abstract

Inflammatory bowel disease (IBD) is an intestinal inflammatory disorder. Exogenous hydrogen sulfide (H2S) donors such as diallyl trisulfide (DATS) have been used as anti-inflammatory mediators. However, an ideal method of administering DATS has yet to be established owing to its poor water solubility. Herein, a self-spray coating system that is derived from a DATS-loaded capsule with foaming capability (CAP-w-FC) is proposed for treating colitis. Following the rectal administration of CAP-w-FC into rats bearing colitis and its subsequent dissolution in the intestinal fluid, a spray coating system is self-assembled in situ. This system greatly promotes the dissolution of the poorly water-soluble DATS by producing nano-scaled micellar particles that are sprayed onto the large luminal surface of the colorectal tract. Following the internalization of the micellar particles by colon epithelial cells, their loaded DATS reacts with intracellular glutathione to yield H2S. This exogenous H2S then diffuses through plasma membranes to carry out its biological functions, including suppressing the overproduction of pro-inflammatory cytokines, inhibiting the adhesion of macrophages on the vascular endothelium, and repairing colonic inflamed ...Continue Reading

Citations

Dec 30, 2020·Antioxidants & Redox Signaling·Peter RoseYi-Zhun Zhu
Oct 27, 2020·Bioactive Materials·Bingyang LuNan Huang
Feb 20, 2021·Molecular Pharmaceutics·Brianna CoteAdam W G Alani
May 1, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhaoyuan GuoJing Xie
Sep 21, 2019·ACS Nano·Lichan ChenJibin Song

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