In situ separation of lactic acid from fermentation broth using ion exchange resins.

Journal of Industrial Microbiology & Biotechnology
Seyed Ahmad Ataei, Ebrahim Vasheghani-Farahani

Abstract

Lactic acid fermentation is an end product inhibited reaction. In situ separation of lactic acid from fermentation broth using ion exchange resins was investigated and compared with conventional fermentation system. Amberlite resin (IRA-400, Cl-) was used to separate lactic acid from fermentation broth and pH was controlled online with an automatic pH controller. The effect of process variables on lactic acid production by Lactobacillus casei in whey permeate was studied. The maximum productivity was obtained at pH=6.1, T=37 degrees C and impeller speed=200 rpm. The maximum concentration of lactic acid at optimum condition was found to be 37.4 g/L after 38 h of fermentation using in situ separation system. The productivity of in situ separation system was five times increased in comparison with conventional system.

References

Jan 1, 1983·Annals of the New York Academy of Sciences·H Y Wang
Dec 6, 2000·Bioseparation·M JärvinenJ Sohlo
Nov 5, 2003·Journal of Biochemical and Biophysical Methods·Felix StonekWalter Tschugguel
Apr 1, 2004·Applied Biochemistry and Biotechnology·Hanjing HuangDavid E Ramey

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Citations

May 27, 2010·Applied Biochemistry and Biotechnology·Yong ZhangShaoyuan Shi
Feb 12, 2014·Microbial Cell Factories·Haibo ZhangMo Xian
Jul 30, 2014·Biotechnology Advances·Wouter Van HeckeHeleen De Wever
Dec 7, 2017·Frontiers in Microbiology·Majdiah OthmanMurni Halim
May 29, 2018·Applied Microbiology and Biotechnology·Mamata SinghviKenji Sonomoto

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