In situ small-angle X-ray scattering studies of sterically-stabilized diblock copolymer nanoparticles formed during polymerization-induced self-assembly in non-polar media

Chemical Science
Matthew J DerryS P Armes

Abstract

Reversible addition-fragmentation chain transfer (RAFT) dispersion polymerization of benzyl methacrylate (BzMA) is utilized to prepare a series of poly(stearyl methacrylate)-poly(benzyl methacrylate) (PSMA-PBzMA) diblock copolymer nano-objects at 90 °C directly in mineral oil. Polymerization-induced self-assembly (PISA) occurs under these conditions, with the resulting nanoparticles exhibiting spherical, worm-like or vesicular morphologies when using a relatively short PSMA13 macromolecular chain transfer agent (macro-CTA), as confirmed by transmission electron microscopy (TEM) and small-angle X-ray scattering (SAXS) studies. Only kinetically-trapped spherical nanoparticles are obtained when using longer macro-CTAs (e.g. PSMA18 or PSMA31), with higher mean degrees of polymerization (DPs) for the PBzMA core-forming block simply producing progressively larger spheres. SAXS is used for the first time to monitor the various morphological transitions that occur in situ during the RAFT dispersion polymerization of BzMA when targeting either spheres or vesicles as the final copolymer morphology. This powerful characterization technique enables the evolution of particle diameter, mean aggregation number, number of copolymer chains per ...Continue Reading

References

Feb 9, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Nadia OuartiRedouane Borsali
Jun 16, 2005·Journal of the American Chemical Society·Giuseppe Battaglia, Anthony J Ryan
Oct 24, 2006·Chemical Society Reviews·Rachel K O'ReillyKaren L Wooley
May 23, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Reinhard SigelHelmut Schlaad
Aug 15, 2008·Accounts of Chemical Research·Graeme MoadSan H Thang
Mar 27, 2009·The Journal of Physical Chemistry. B·Soo-Hyung ChoiTimothy P Lodge
Mar 4, 2010·Chemical Communications : Chem Comm·Stéphanie BoisséBernadette Charleux
Jan 1, 1990·Annual Review of Physical Chemistry·F S Bates, G H Fredrickson
Jun 24, 2010·Nature Chemistry·Joe B GilroyIan Manners
Feb 16, 2010·Macromolecular Rapid Communications·Wen-Ming WanCai-Yuan Pan
Feb 18, 2009·Macromolecular Rapid Communications·Adam BlanazsAnthony J Ryan
Aug 19, 2011·Journal of the American Chemical Society·Adam BlanazsSteven P Armes
Aug 23, 2011·Journal of the American Chemical Society·Shinji SugiharaAndrew L Lewis
May 16, 2012·Journal of the American Chemical Society·Adam BlanazsSteven P Armes
Nov 22, 2013·Macromolecular Rapid Communications·Bunyamin KaragozThomas P Davis
Apr 1, 2014·Journal of the American Chemical Society·Lee A FieldingSteven P Armes
May 14, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·David J GrowneySteven P Armes
Jun 27, 2014·Journal of the American Chemical Society·Nicholas J Warren, Steven P Armes
Oct 3, 2014·The Review of Scientific Instruments·Daniel Hermida-MerinoWim Bras
Sep 8, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·David J GrowneySteven P Armes
Feb 1, 2015·Chemical Science·C Adrian FiggBrent S Sumerlin

❮ Previous
Next ❯

Citations

Oct 29, 2018·Small·Tamuka ChidanguroYoan C Simon
Sep 15, 2018·Macromolecular Rapid Communications·Gong Cheng, Juan Pérez-Mercader
Mar 13, 2020·Nanoscale·Elaine A KellyRachel C Evans
Jul 3, 2020·Angewandte Chemie·Yin NingSteven P Armes
May 10, 2018·Scientific Reports·Dominic W HaywardMichael Gradzielski
Jan 11, 2017·Angewandte Chemie·Matthew J DerrySteven P Armes
Jul 12, 2019·Proceedings. Mathematical, Physical, and Engineering Sciences·Gregory N SmithSteven P Armes
Aug 10, 2018·Macromolecular Rapid Communications·Song Yang KhorThomas P Davis
Jul 31, 2021·Chemical Reviews·Aoon RizviJoseph P Patterson
Jul 24, 2021·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Wim BrasRoberto Felici
Dec 10, 2019·ACS Applied Materials & Interfaces·Liang QiuCai-Yuan Pan
Dec 17, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Saul J Hunter, Steven P Armes
Jul 19, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Mohammad VakiliMartin Trebbin
Jan 15, 2021·Journal of the American Chemical Society·Adam Czajka, Steven P Armes
Jan 31, 2019·Journal of the American Chemical Society·Yin NingSteven P Armes
Sep 21, 2021·Soft Matter·Matthew J DerrySteven P Armes

❮ Previous
Next ❯

Methods Mentioned

BETA
PISA
RAFT
X-ray
transmission electron microscopy
dynamic light scattering
SMA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.