In situ strategy for bone repair by facilitated endogenous tissue engineering

Colloids and Surfaces. B, Biointerfaces
Jingdi ChenQiqing Zhang

Abstract

Traditional tissue engineering procedures are expensive and time consuming. Facilitated endogenous tissue engineering (FETE) provides a solution that can avoid the ex vivo culture of autologous cells and initiate in situ reparative endogenous repair processes in vivo. This method involves fabricating a porous scaffold that mimics the environment present during the bone formation process, consisting of components that provide biomimetic interfacial interactions to cells. After the scaffold is implanted, progenitor cells provided by autologous bone marrow and surrounding tissues then differentiate to bone cells under the direction of the in situ scaffold. This paper reports a biomimetic method to prepare a hierarchically structured hybrid scaffold. Bone-like nano hydroxyapatite (HA) was crystallized from a collagen and chitosan (CC) matrix to form a porous scaffold. The in vivo study demonstrates that this nanohybrid scaffold supports excellent bone repair. This means that the FETE approach, in which the cell culture portion of traditional tissue engineering takes place in vivo, can promote the intrinsic regenerative potential of endogenous tissues.

References

Nov 23, 2006·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Grazyna StrzelczakJacek Michalik
Feb 14, 2007·Biomaterials·Jing Di ChenXue Tao Shi
Aug 25, 2007·Nanomedicine·Casey K ChanSeeram Ramakrishnan
Nov 23, 2007·Advanced Drug Delivery Reviews·Marco BiondiPaolo Antonio Netti
Feb 26, 2008·Acta Biomaterialia·Biraja P KanungoLorna J Gibson
May 3, 2008·Journal of Materials Science. Materials in Medicine·Xiupeng WangHao Dong
Jul 16, 2008·Journal of Cellular and Molecular Medicine·Lilian SteffensGünter Finkenzeller
Dec 25, 2008·Journal of the Royal Society, Interface·Hideki YoshikawaAkira Myoui
Jul 22, 2009·Journal of Biomaterials Science. Polymer Edition·Jing Di ChenXiaofeng Chen
Mar 29, 2011·Acta Biomaterialia·Hongjian Zhou, Jaebeom Lee
Jun 22, 2011·Tissue Engineering. Part a·Jangho KimJong Hoon Chung
Jul 23, 2011·Nature Chemistry·Morgan D MagerMolly M Stevens
Aug 4, 2011·Tissue Engineering. Part B, Reviews·Ana Rita Costa-PintoNuno M Neves
Nov 30, 2011·Journal of Biomedical Materials Research. Part a·Ramjee PallelaSe-Kwon Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Materials Science. Materials in Medicine
S C MendesC A Van Blitterswijk
Deutsche medizinische Wochenschrift
B GiereA Haverich
Journal of Biomedical Materials Research. Part B, Applied Biomaterials
I ManjubalaKlaus D Jandt
© 2021 Meta ULC. All rights reserved