In situ synthesis of homochiral metal-organic framework in capillary column for capillary electrochromatography enantioseparation

Journal of Chromatography. a
Congjie PanXingguo Chen

Abstract

Homochiral metal-organic frameworks (MOFs) are promising as porous stationary phase for open-tubular capillary electrochromatography (OT-CEC) enantioseparation owing to their fine-tuned pore sizes and large surface areas. In this work, the homochiral MOF AlaZnCl was successfully coated on the inner wall of fused silica capillary by an in situ, layer-by-layer self-assembly approach at room temperature. The results of scanning electron microscopy (SEM), X-ray diffraction (XRD), streaming potential (SP) and Fourier-transform infrared spectroscopy (FT-IR) indicated that the homochiral MOF AlaZnCl was successfully coated on the capillary inner wall. To evaluate the performance of the homochiral MOF AlaZnCl coated capillary column, the enantioseparation was carried out by using six amine drugs and monoamine neurotransmitters as model analytes and excellent enantioseparation efficiency was achieved. Run-to-run, day-to-day, and column-to-column relative standard deviations (RSDs) were all less than 5%. Moreover, the separation efficiency of the homochiral MOF AlaZnCl coated capillary column did not decrease obviously over 100 runs.

References

Sep 16, 1999·Journal of Chromatography. a·H Sirén, U Karjalainen
Sep 11, 2002·Electrophoresis·Anurag S RathoreLuis A Colón
May 17, 2003·Science·Nathaniel L RosiOmar M Yaghi
Sep 10, 2004·Journal of Chromatography. a·Elizabeth Guihen, Jeremy D Glennon
May 21, 2008·Chemical Communications : Chem Comm·Yeonshick Yoo, Hae-Kwon Jeong
Apr 23, 2009·Chemical Society Reviews·Jian-Rong LiHong-Cai Zhou
Jul 15, 2011·Journal of the American Chemical Society·Sheng-Ming XieLi-Ming Yuan
Oct 1, 2011·Chemical Communications : Chem Comm·Mohan PadmanabanStefan Kaskel
May 26, 2012·Chemical Communications : Chem Comm·Hui XuGuodong Qian
Jul 19, 2012·Chemical Communications : Chem Comm·Koichi TanakaAtsushi Ohnish
Jan 31, 2013·Analytical and Bioanalytical Chemistry·Sheng-Ming XieLi-Ming Yuan
Nov 19, 2013·Analytical Biochemistry·Cemil Aydoğan, Adil Denizli
Sep 10, 2014·Journal of Chromatography. a·Sheng-Ming XieLi-Ming Yuan

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Citations

Jun 5, 2016·Journal of Pharmaceutical and Biomedical Analysis·Jialiang GuoZhengjin Jiang
May 27, 2016·Journal of Separation Science·Yongqin LvFrantisek Svec
Jul 14, 2016·Journal of Chromatographic Science·Jiang-Rong YangLi-Ming Yuan
Oct 27, 2015·Electrophoresis·Faustino M TarongoyJoselito P Quirino
Jul 7, 2017·Electrophoresis·Miguel Ángel González-CurbeloJavier Hernández-Borges
Aug 13, 2017·Electrophoresis·Yuanyuan LiuChao Yan
Nov 28, 2020·Analytical Methods : Advancing Methods and Applications·Ying ZhangYong Wang
Oct 19, 2019·Analytica Chimica Acta·Mohamed Adel AhmedJoselito P Quirino

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